Yoshida J, Ohishi T, Abe H, Ohba SI, Inoue H, Usami I, Amemiya M, Oriez R, Sakashita C, Dan S, Sugawara M, Kawaguchi T, Ueno J, Asano Y, Ikeda A, Takamatsu M, Amori G, Kondoh Y, Honda K, Osada H, Noda T, Watanabe T, Shimizu T, Shibasaki M, Kawada M.: Mitochondrial complex I inhibitors suppress tumor growth through concomitant acidification of the intra- and extracellular environment. iScience, 24(12): 103497 (2021) [ doi: 10.1016/j.isci.2021.103497 ]
Lee JW, Ong TG, Samian MR, Teh AH, Watanabe N, Osada H, Ong EBB.: Screening of selected ageing-related proteins that extend chronological life span in yeast Saccharomyces cerevisiae. Sci Rep, 11(1): 24148 (2021) [ doi: 10.1038/s41598-021-03490-7 ]
Ishihama N, Choi SW, Noutoshi Y, Saska I, Asai S, Takizawa K, He SY, Osada H, Shirasu K.: Oxicam-type non-steroidal anti-inflammatory drugs inhibit NPR1-mediated salicylic acid pathway. Nat Commun, 12(1): 7303 (2021) [ doi: 10.1038/s41467-021-27489-w ]
Kashiwa T, Motoyama T, Yoshida K, Yun CS, Osada H.: Tenuazonic acid production is dispensable for virulence, but its biosynthetic gene expression pattern is associated with the infection of Pyricularia oryzae. Biosci Biotechnol Biochem, 86(1): 135-139 (2021) [ doi: 10.1093/bbb/zbab195 ]
Lopez JAV, Nogawa T, Yoshida K, Futamura Y, Osada H.: 2-Methylthio-N7-methyl-cis-zeatin, a new antimalarial natural product isolated from a Streptomyces culture. Biosci Biotechnol Biochem, 86(1): 31-36 (2021) [ doi: 10.1093/bbb/zbab192 ]
Kawatani M, Aono H, Shimizu T, Ohkura S, Hiranuma S, Muroi M, Ogawa N, Ohishi T, Ohba SI, Kawada M, Yamazaki K, Dan S, Osada H.: Identification of dihydroorotate dehydrogenase inhibitors─indoluidins─that inhibit cancer cell growth. ACS Chem Biol, 16(11): 2570-2580 (2021) [ doi: 10.1021/acschembio.1c00625 ]
Zhu H, Cai Y, Ma S, Futamura Y, Li J, Zhong W, Zhang X, Osada H, Zou H.: Privileged biorenewable secologanin-based diversity-oriented synthesis for pseudo-natural alkaloids: uncovering novel neuroprotective and antimalarial frameworks. ChemSusChem, 14(23): 5320-5327 (2021) [ doi: 10.1002/cssc.202101868 ]
Jang JP, Kwon MC, Nogawa T, Takahashi S, Osada H, Ahn JS, Ko SK, Jang JH.: Thiolactomide: A New Homocysteine Thiolactone Derivative from Streptomyces sp. with Neuroprotective Activity. J Microbiol Biotechnol, 31(12): 1667-1671 (2021) [ doi: 10.4014/jmb.2108.08015 ]
Kako S, Tabuchi M, Miyazawa K, Tanaka M, Minamoto C, Asano Y, Kimura F, Aoki Y, Sato T, Kawatani M, Osada H, Maeda H, Goto S.: Does local injection of reveromycin A inhibit tooth movement without causing systemic side effects? Eur J Orthod, 43(6): 658-664 (2021) [ doi: 10.1093/ejo/cjaa067 ]
Liu H, Futamura Y, Wu H, Ishiyama A, Zhang T, Shi T, Zheng Q, Iwatsuki M, Ōmura S, Zou H, Osada H.: Discovery of 3-cinnamamido-N-substituted benzamides as potential antimalarial agents Med Chem, 17(10): 1207-1218 (2021) [ doi: 10.2174/1573406416666200817160708 ]
Nakatani K, Maehama T, Nishio M, Otani J, Yamaguchi K, Fukumoto M, Hikasa H, Hagiwara S, Nishina H, Mak TW, Honma T, Kondoh Y, Osada H, Yoshida M, Suzuki A.: Alantolactone is a natural product that potently inhibits YAP1/TAZ through promotion of reactive oxygen species accumulation. Cancer Sci, 112(10): 4303-4316 (2021) [ doi: 10.1111/cas.15079 ]
Moon JY, Adams E, Miyazaki T, Kondoh Y, Muroi M, Watanabe N, Osada H, Shin R.: Cesium tolerance is enhanced by a chemical which binds to BETA-GLUCOSIDASE 23 in Arabidopsis thaliana. Sci Rep, 11(1): 21109 (2021) [ doi: 10.1038/s41598-021-00564-4 ]
Sakamoto T, Fukui Y, Kondoh Y, Honda K, Shimizu T, Hara T, Hayashi T, Saitoh Y, Murakami Y, Inoue JI, Kaneko S, Osada H, Seiki M.: Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock. Commun Biol, 4(1): 1165 (2021) [ doi: 10.1038/s42003-021-02701-1 ]
Fujiyama K, Kato N, Re S, Kinugasa K, Watanabe K, Takita R, Nogawa T, Hino T, Osada H, Sugita Y, Takahashi S, Nagano S.: Molecular Basis for Two Stereoselective Diels-Alderases that Produce Decalin Skeletons. Angew Chem Int Ed Engl, 60(41): 22401-22410 (2021) [ doi: 10.1002/anie.202106186 ]
Motoyama T, Ishii T, Kamakura T, Osada H.: Screening of tenuazonic acid production-inducing compounds and identification of NPD938 as a regulator of fungal secondary metabolism. Biosci Biotechnol Biochem, 85(10): 2200-2208 (2021) [ doi: 10.1093/bbb/zbab143 ]
Miyazawa K, Asano Y, Tabuchi M, Kako S, Kawatani M, Osada H, Maeda H, Goto S.: Local administration of ReveromycinA ointment suppressed alveolar bone loss in mice. J Pharmacol Sci, 147(1): 40-47 (2021) [ doi: 10.1016/j.jphs.2021.05.011 ]
Sakai K, Takao R, Koshino H, Futamura Y, Osada H, Takahashi S.: 6,9-Dihydroxytetrangulol, a novel angucyclinone antibiotic accumulated in kiqO gene disruptant in the biosynthesis of kinanthraquinone. J Antibiot, 74(9): 593-595 (2021) [ doi: 10.1038/s41429-021-00442-1 ]
Safizadeh H, Simpkins SW, Nelson J, Li SC, Piotrowski JS, Yoshimura M, Yashiroda Y, Hirano H, Osada H, Yoshida M, Boone C, Myers CL.: Improving measures of chemical structural similarity using machine learning on chemical-genetic interactions. J Chem Inf Model, 61(9): 4156-4172 (2021) [ doi: 10.1021/acs.jcim.0c00993 ]
Rawa MSA, Nogawa T, Okano A, Futamura Y, Wahab HA, Osada H.: Zealpeptaibolin, an 11-mer cytotoxic peptaibol group with 3 Aib-Pro motifs isolated from Trichoderma sp. RK10-F026. J Antibiot, 74(8): 485-495 (2021) [ doi: 10.1038/s41429-021-00429-y ]
Kawatani M, Aono H, Hiranuma S, Shimizu T, Muroi M, Ogawa N, Ohishi T, Ohba SI, Kawada M, Nogawa T, Okano A, Hashizume D, Osada H.: Identification of a small-molecule glucose transporter inhibitor, glutipyran, that inhibits cancer cell growth. ACS Chem Biol, 16(8): 1576-1586 (2021) [ doi: 10.1021/acschembio.1c00480 ]
Yoshida K, Kondoh Y, Nakano T, Bolortuya B, Kawabata S, Iwahashi F, Nagano E, Osada H.: New abscisic acid derivatives revealed adequate regulation of stomatal, transcriptional, and developmental responses to conquer drought. ACS Chem Biol, 16(8): 1566-1575 (2021) [ doi: 10.1021/acschembio.1c00451 ]
Nagashima S, Maruyama J, Honda K, Kondoh Y, Osada H, Nawa M, Nakahama KI, Ishigami-Yuasa M, Kagechika H, Sugimura H, Iwasa H, Arimoto-Matsuzaki K, Nishina H, Hata Y.: CSE1L promotes nuclear accumulation of transcriptional coactivator TAZ and enhances invasiveness of human cancer cells. J Biol Chem, 297(1): 100803 (2021) [ doi: 10.1016/j.jbc.2021.100803 ]
Lopez JAV, Nogawa T, Futamura Y, Aono H, Hashizume D, Osada H.: N-Acetyl-α-hydroxy-β-oxotryptamine, a racemic natural product isolated from Streptomyces sp. 80H647. J Antibiot, 74: 477–479 (2021) [ doi: 10.1038/s41429-021-00420-7 ]
Takayama KI, Honma T, Suzuki T, Kondoh Y, Osada H, Suzuki Y, Yoshida M, Inoue S.: Targeting epigenetic and post-transcriptional gene regulation by PSF impairs hormone therapy-refractory cancer growth. Cancer Res, 81(13): 3495-3508 (2021) [ doi: 10.1158/0008-5472.CAN-20-3819 ]
Wilke J, Kawamura T, Xu H, Brause A, Friese A, Metz M, Schepmann D, Wünsch B, Artacho-Cordón A, Nieto FR, Watanabe N, Osada H, Ziegler S, Waldmann H.: Discovery of a σ1 receptor antagonist by combination of unbiased cell painting and thermal proteome profiling. Cell Chem Biol, 28(6): 848-854.e5 (2021) [ doi: 10.1016/j.chembiol.2021.01.009 ]
Cheng L, Osada H, Xing T, Yoshida M, Xiang L, Qi J.: The insulin receptor: a potential target of amarogentin isolated from Gentiana rigescens franch that induces neurogenesis in PC12 cells. Biomedicines, 9(5): 581 (2021) [ doi: 10.3390/biomedicines9050581 ]
Hara T, Toyoshima M, Hisano Y, Balan S, Iwayama Y, Aono H, Futamura Y, Osada H, Owada Y, Yoshikawa T.: Glyoxalase I disruption and external carbonyl stress impair mitochondrial function in human induced pluripotent stem cells and derived neurons. Transl Psychiatry, 11(1): 275 (2021) [ doi: 10.1038/s41398-021-01392-w ]
Furuyama Y, Motoyama T, Nogawa T, Kamakura T, Osada H.: Dihydropyriculol produced by Pyricularia oryzae inhibits the growth of Streptomyces griseus. Biosci Biotechnol Biochem, 85(5): 1290-1293 (2021) [ doi: 10.1093/bbb/zbab021 ]
Watanabe K, Bat-Erdene A, Tenshin H, Cui Q, Teramachi J, Hiasa M, Oda A, Harada T, Miki H, Sogabe K, Oura M, Sumitani R, Mitsui Y, Endo I, Tanaka E, Kawatani M, Osada H, Matsumoto T, Abe M.: Reveromycin A, a novel acid-seeking agent, ameliorates bone destruction and tumor growth in multiple myeloma. Haematologica, 106(4): 1172-1177 (2021) [ doi: 10.3324/haematol.2019.244418 ]
Kobayashi H, Hatakeyama H, Nishimura H, Yokota M, Suzuki S, Tomabechi Y, Shirouzu M, Osada H, Mimaki M, Goto YI, Yoshida M.: Chemical reversal of abnormalities in cells carrying mitochondrial DNA mutations. Nat Chem Biol, 17(3): 335-343 (2021) [ doi: 10.1038/s41589-020-00676-4 ]
Takao R, Sakai K, Koshino H, Osada H, Takahashi S.: Identification of the kinanthraquinone biosynthetic gene cluster by expression of an atypical response regulator. Biosci Biotechnol Biochem, 85(3): 714-721 (2021) [ doi: 10.1093/bbb/zbaa082 ]
Jang M, Hara S, Kim GH, Kim SM, Son S, Kwon M, Ryoo IJ, Seo H, Kim MJ, Kim ND, Soung NK, Kwon YT, Kim BY, Osada H, Jang JH, Ko SK, Ahn JS.: Dutomycin induces autophagy and apoptosis by targeting the serine protease Inhibitor SERPINB6. ACS Chem Biol, 16(2): 360-370 (2021) [ doi: 10.1021/acschembio.0c00889 ]
Furuyama Y, Motoyama T, Nogawa T, Hayashi T, Hirota H, Kiyota H, Kamakura T, Osada H.: Controlling the production of phytotoxin pyriculol in Pyricularia oryzae by aldehyde reductase. Biosci Biotechnol Biochem, 85(1): 126-133 (2021) [ doi: 10.1093/bbb/zbaa035 ]
Rawa MSA, Nogawa T, Okano A, Futamura Y, Nakamura T, Wahab HA, Osada H.: A new peptaibol, RK-026A, from the soil fungus Trichoderma sp. RK10-F026 by culture condition-dependent screening. Biosci Biotechnol Biochem, 85(1): 69-76 (2021) [ doi: 10.1093/bbb/zbaa051 ]
[ doi: 10.1016/j.isci.2021.103497 ]