Yagasaki Y, Sudo T, Osada H.: Exip, a splicing variant of p38alpha, participates in interleukin-1 receptor proximal complex and downregulates NF-kappaB pathway. FEBS Lett, 575(1-3): 136-140 (2004) [ doi: 10.1016/j.febslet.2004.08.050 ]
Usui T, Kazami S, Dohmae N, Mashimo Y, Kondo H, Tsuda M, Terasaki AG, Ohashi K, Kobayashi J, Osada H.: Amphidinolide h, a potent cytotoxic macrolide, covalently binds on actin subdomain 4 and stabilizes actin filament. Chem Biol, 11(9): 1269-1277 (2004) [ doi: 10.1016/j.chembiol.2004.07.014 ]
Sekine M, Okada K, Seio K, Obata T, Sasaki T, Kakeya H, Osada H.: Synthesis of a biotin-conjugate of phosmidosine O-ethyl ester as a G1 arrest antitumor drug. Bioorg Med Chem, 12(24): 6343-6349 (2004) [ doi: 10.1016/j.bmc.2004.09.037 ]
Sekine M, Okada K, Seio K, Kakeya H, Osada H, Sasaki T.: Structure-activity relationship of phosmidosine: importance of the 7,8-dihydro-8-oxoadenosine residue for antitumor activity. Bioorg Med Chem, 12(19): 5193-5201 (2004) [ doi: 10.1016/j.bmc.2004.07.021 ]
Nagumo Y, Kakeya H, Yamaguchi J, Uno T, Shoji M, Hayashi Y, Osada H.: Structure-activity relationships of epolactaene derivatives: structural requirements for inhibition of Hsp60 chaperone activity. Bioorg Med Chem Lett, 14(17): 4425-4429 (2004) [ doi: 10.1016/j.bmcl.2004.06.054 ]
Bae EY, Oh H, Oh WK, Kim MS, Kim BS, Kim BY, Sohn CB, Osada H, Ahn JS.: A new VHR dual-specificity protein tyrosine phosphatase inhibitor from Dendrobium moniliforme. Planta Med, 70(9): 869-870 (2004) [ doi: 10.1055/s-2004-827238 ]
Tamura Y, Simizu S, Osada H.: The phosphorylation status and anti-apoptotic activity of Bcl-2 are regulated by ERK and protein phosphatase 2A on the mitochondria. FEBS Lett, 569(1-3): 249-255 (2004) [ doi: 10.1016/j.febslet.2004.06.003 ]
Kondoh M, Suzuki I, Sato M, Nagashima F, Simizu S, Harada M, Fujii M, Osada H, Asakawa Y, Watanabe Y.: Kaurene diterpene induces apoptosis in human leukemia cells partly through a caspase-8-dependent pathway. J Pharmacol Exp Ther, 311(1): 115-122 (2004) [ doi: 10.1124/jpet.104.069690 ]
Ishida K, Simizu S, Teruya T, Wierzba MK, Osada H.: Rational design and synthesis of novel heparan sulfate mimetic compounds as antiadhesive agents. Bioorg Med Chem Lett, 14(10): 2505-2509 (2004) [ doi: 10.1016/j.bmcl.2004.03.009 ]
Simizu S, Ishida K, Wierzba MK, Osada H.: Secretion of heparanase protein is regulated by glycosylation in human tumor cell lines. J Biol Chem, 279(4): 2697-2703 (2004) [ doi: 10.1074/jbc.M300541200 ]
Sekine M, Okada K, Seio K, Kakeya H, Osada H, Obata T, Sasaki T.: Synthesis of chemically stabilized phosmidosine analogues and the structure--activity relationship of phosmidosine. J Org Chem, 69(2): 314-326 (2004) [ doi: 10.1021/jo0351466 ]
Ishida K, Hirai G, Murakami K, Teruya T, Simizu S, Sodeoka M, Osada H.: Structure-based design of a selective heparanase inhibitor as an antimetastatic agent. Mol Cancer Ther, 3(9): 1069-1077 (2004) [url]
Usui T, Watanabe H, Nakayama H, Tada Y, Kanoh N, Kondoh M, Asao T, Takio K, Watanabe H, Nishikawa K, Kitahara T, Osada H.: The anticancer natural product pironetin selectively targets Lys352 of alpha-tubulin. Chem Biol, 11(6): 799-806 (2004) [ doi: 10.1016/j.chembiol.2004.03.028 ]
Shoji M, Imai H, Shiina I, Kakeya H, Osada H, Hayashi Y.: Different reaction modes for the oxidative dimerization of epoxyquinols and epoxyquinones. Importance of intermolecular hydrogen-bonding. J Org Chem, 69(5): 1548-1556 (2004) [ doi: 10.1021/jo0355303 ]
Ishida K, Teruya T, Simizu S, Osada H.: Exploitation of heparanase inhibitors from microbial metabolites using an efficient visual screening system. J Antibiot, 57(2): 136-142 (2004) [ doi: 10.7164/antibiotics.57.136 ]
Mitsui T, Miyake Y, Kakeya H, Osada H, Kataoka T.: ECH, an epoxycyclohexenone derivative that specifically inhibits Fas ligand-dependent apoptosis in CTL-mediated cytotoxicity. J Immunol, 172(6): 3428-3436 (2004) [ doi: 10.4049/jimmunol.172.6.3428 ]
Asami Y, Kakeya H, Onose R, Chang YH, Toi M, Osada H.: RK-805, an endothelial-cell-growth Inhibitor produced by Neosartorya sp., and a docking model with methionine aminopeptidase-2. Tetrahedron, 60, 7085-7091 (2004) [url]
Watanabe N, Arai H, Nishihara Y, Taniguchi M, Watanabe N, Hunter T, Osada H.: M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP. Proc Natl Acad Sci U S A, 101(13): 4419-4424 (2004) [ doi: 10.1073/pnas.0307700101 ]
Simizu S, Tamura Y, Osada H.: Dephosphorylation of Bcl-2 by protein phosphatase 2A results in apoptosis resistance. Cancer Sci, 95(3): 266-270 (2004) [ doi: 10.1111/j.1349-7006.2004.tb02214.x ]
[ doi: 10.1016/j.febslet.2004.08.050 ]