Shoji M, Uno T, Kakeya H, Onose R, Shiina I, Osada H, Hayashi Y.: Enantio- and diastereoselective total synthesis of EI-1941-1, -2, and -3, inhibitors of interleukin-1beta converting enzyme, and biological properties of their derivatives. J Org Chem, 70(24): 9905-9915 (2005) [ doi: 10.1021/jo0516436 ]
Sudo T, Kawai K, Matsuzaki H, Osada H.: p38 mitogen-activated protein kinase plays a key role in regulating MAPKAPK2 expression. Biochem Biophys Res Commun, 337(2): 415-421 (2005) [ doi: 10.1016/j.bbrc.2005.09.063 ]
Hayashi Y, Shoji M, Mukaiyama T, Gotoh H, Yamaguchi S, Nakata M, Kakeya H, Osada H.: First asymmetric total synthesis of synerazol, an antifungal antibiotic, and determination of its absolute stereochemistry. J Org Chem, 70(14): 5643-5654 (2005) [ doi: 10.1021/jo050664x ]
Han XX, Cui CB, Gu QQ, Zhu WM, Liu HB, Gu JY, Osada, H.: ZHD-0501, a novel naturally occurring staurosporine analog from Actinomadura sp. 007. Tetrahedron Lett., 46, 6137-6140 (2005)
Mitsui T, Miyake Y, Kakeya H, Hayashi Y, Osada H, Kataoka T.: RKTS-33, an epoxycyclohexenone derivative that specifically inhibits Fas ligand-dependent apoptosis in CTL-mediated cytotoxicity. Biosci Biotechnol Biochem, 69(10): 1923-1928 (2005) [ doi: 10.1271/bbb.69.1923 ]
Nakazawa J, Watanabe N, Imoto M, Osada H.: Mutational analysis of growth arrest and cellular localization of human immunodeficiency virus type 1 Vpr in the budding yeast, Saccharomyces cerevisiae. J Gen Appl Microbiol, 51(4): 245-256 (2005) [ doi: 10.2323/jgam.51.245 ]
Muguruma H, Yano S, Kakiuchi S, Uehara H, Kawatani M, Osada H, Sone S.: Reveromycin A inhibits osteolytic bone metastasis of small-cell lung cancer cells, SBC-5, through an antiosteoclastic activity. Clin Cancer Res, 11(24 Pt 1): 8822-8828 (2005) [ doi: 10.1158/1078-0432.CCR-05-1335 ]
Watanabe N, Arai H, Iwasaki J, Shiina M, Ogata K, Hunter T, Osada H.: Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways. Proc Natl Acad Sci U S A, 102(33): 11663-11668 (2005) [ doi: 10.1073/pnas.0500410102 ]
Simizu S, Takagi S, Tamura Y, Osada H.: RECK-mediated suppression of tumor cell invasion is regulated by glycosylation in human tumor cell lines. Cancer Res, 65(16): 7455-7461 (2005) [ doi: 10.1158/0008-5472.CAN-04-4446 ]
Kanoh N, Honda K, Simizu S, Muroi M, Osada H.: Photo-cross-linked small-molecule affinity matrix for facilitating forward and reverse chemical genetics. Angew Chem Int Ed Engl, 44(23): 3559-3562 (2005) [ doi: 10.1002/anie.200462370 ]
Yamaguchi J, Kakeya H, Uno T, Shoji M, Osada H, Hayashi Y.: Determination by asymmetric total synthesis of the absolute configuration of lucilactaene, a cell-cycle inhibitor in p53-transfected cancer cells. Angew Chem Int Ed Engl, 44(20): 3110-3115 (2005) [ doi: 10.1002/anie.200500060 ]
Teruya T, Simizu S, Kanoh N, Osada H.: Phoslactomycin targets cysteine-269 of the protein phosphatase 2A catalytic subunit in cells. FEBS Lett, 579(11): 2463-2468 (2005) [ doi: 10.1016/j.febslet.2005.03.049 ]
Shoji M, Imai H, Mukaida M, Sakai K, Kakeya H, Osada H, Hayashi Y.: Total synthesis of epoxyquinols A, B, and C and epoxytwinol A and the reactivity of a 2H-pyran derivative as the diene component in the Diels-Alder reaction. J Org Chem, 70(1): 79-91 (2005) [ doi: 10.1021/jo048425h ]
Kakeya H, Onose R, Koshino H, Osada H.: Epoxytwinol A, a novel unique angiogenesis inhibitor with C2 symmetry, produced by a fungus. Chem Commun (Camb), 2005(20): 2575-2577 (2005) [ doi: 10.1039/b501392e ]
Nagumo Y, Kakeya H, Shoji M, Hayashi Y, Dohmae N, Osada H.: Epolactaene binds human Hsp60 Cys442 resulting in the inhibition of chaperone activity. Biochem J, 387(Pt 3): 835-840 (2005) [ doi: 10.1042/BJ20041355 ]
[ doi: 10.1021/jo0516436 ]