RIKEN Center for Sustainable Resource Science
Chemical Biology Group (Archives)

Original Articles 2019

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1. Kanoh N, Kawamata-Asano A, Suzuki K, Takahashi Y, Miyazawa T, Nakamura T, Moriya T, Hirano H, Osada H, Iwabuchi Y, Takahashi S.: An integrated screening system for the selection of exemplary substrates for natural and engineered cytochrome P450s.
   Sci Rep, 9(1): 18023 (2019) [ doi: 10.1038/s41598-019-54473-8 ]
2. Kwong MMY, Lee JW, Samian MR, Watanabe N, Osada H, Ong EBB.: Comparison of microplate- and bottle-based methods to age yeast for chronological life span assays.
   J Microbiol Methods, 167:105743(2019) [ doi: 10.1016/j.mimet.2019.105743 ]
3. Yamamoto K, Futamura Y, Uson-Lopez RA, Aono H, Shimizu T, Osada H.: YO-001A, a new antifungal agent produced by Streptomyces sp. YO15-A001.
   J Antibiot, 72(12): 986-990 (2019) [ doi: 10.1038/s41429-019-0239-z ]
4. Lopez JAV, Nogawa T, Futamura Y, Shimizu T, Osada H.: Nocardamin glucuronide, a new member of the ferrioxamine siderophores isolated from the ascamycin-producing strain Streptomyces sp. 80H647.
   J Antibiot, 72(12): 991-995 (2019) [ doi: 10.1038/s41429-019-0217-5 ]
5. Nogawa T, Kawatani M, Okano A, Futamura Y, Aono H, Shimizu T, Kato N, Kikuchi H, Osada H.: Structure and biological activity of Metarhizin C, a stereoisomer of BR-050 from Tolypocladium album RK17-F0007.
   J Antibiot, 72(12): 996-1000 (2019) [ doi: 10.1038/s41429-019-0229-1 ]
6. Förster T, Shang E, Shimizu K, Sanada E, Schölermann B, Huebecker B, Hahne G, López-Alberca MP, Janning P, Watanabe N, Sievers S, Giordanetto F, Shimizu T, Ziegler S, Osada H, Waldmann H.: 2-Sulfonylpyrimidines target the kinesin HSET via cysteine alkylation.
   Eur J Org Chem, 2019:5486-5496 (2019) [ doi: 10.1002/ejoc.201900586 ]
7. Cai Y, Shao N, Xie H, Futamura Y, Panjikar S, Liu H, Zhu H, Osada H, Zou H: Stereocomplementary chemoenzymatic Pictet–Spengler reactions for formation of rare azepino-indole frameworks: Discovery of antimalarial compounds.
   ACS Catal, 9(8): 7443-7448 (2019) [ doi: 10.1021/acscatal.9b01628 ]
8. Yoshida K, Kondoh Y, Iwahashi F, Nakano T, Honda K, Nagano E, Osada H.: Abscisic acid derivatives with different alkyl chain lengths activate distinct abscisic acid receptor subfamilies.
   ACS Chem Biol, 14(9): 1964-1971 (2019) [ doi: 10.1021/acschembio.9b00453 ]
9. Takase S, Kurokawa R, Kondoh Y, Honda K, Suzuki T, Kawahara T, Ikeda H, Dohmae N, Osada H, Shin-Ya K, Kushiro T, Yoshida M, Matsumoto K.: Mechanism of action of prethioviridamide, an anticancer ribosomally synthesized and post-translationally modified peptide with a polythioamide structure.
   ACS Chem Biol, 14(8): 1819-1828 (2019) [ doi: 10.1021/acschembio.9b00410 ]
10. Li J, Sun K, Muroi M, Gao L, Chang YT, Osada H, Xiang L, Qi J.: Cucurbitacin B induces neurogenesis in PC12 cells and protects memory in APP/PS1 mice.
    J Cell Mol Med, 23(9):6283-6294 (2019) [ doi: 10.1111/jcmm.14514 ]
11. Murashima A, Shinjo K, Katsushima K, Onuki T, Kondoh Y, Osada H, Kagaya N, Shinya K, Kimura H, Yoshida M, Murakami S, Kondo Y.: Identification of a chemical modulator of EZH2-mediated silencing by cell-based high-throughput screening assay.
    J Biochem, 166:41–50 (2019) [ doi: 10.1093/jb/mvz007 ]
12. Farooq U, Pan Y, Lin Y, Wang Y, Osada H, Xiang L, Qi J.: Structure characterization and action mechanism of an antiaging new compound from Gastrodia elata Blume.
    Oxid Med Cell Longev, 2019: 5459862 (2019) [ doi: 10.1155/2019/5459862 ]
13. Shu K, Iwamoto N, Honda K, Kondoh Y, Hirano H, Osada H, Ohno H, Fujii N, Oishi S.: Development of mirror-image screening systems for XIAP BIR3 domain inhibitors.
    Bioconjug Chem, 30(5): 1395-1404 (2019) [ doi: 10.1021/acs.bioconjchem.9b00154 ]
14. Subedi A, Muroi M, Futamura Y, Kawamura T, Aono H, Nishi M, Ryo A, Watanabe N, Osada H.: A novel inhibitor of tumorspheres reveals the activation of the serine biosynthetic pathway upon mitochondrial inhibition.
    FEBS Lett, 593(8): 763-776 (2019) [ doi: 10.1002/1873-3468.13361 ]
15. Panthee S, Takahashi S, Hayashi T, Shimizu T, Osada H.: β-carboline biomediators induce reveromycin production in Streptomyces sp. SN-593.
    Sci Rep, 9(1): 5802 (2019) [ doi: 10.1038/s41598-019-42268-w ]
16. Cheng L, Muroi M, Cao S, Bian L, Osada H, Xiang L, Qi J.: 3β,23,28-Trihydroxy-12-oleanene 3β-caffeate from Desmodium sambuense-induced neurogenesis in PC12 cells mediated by ER stress and BDNF-TrkB signaling pathways.
    Mol Pharm, 16(4): 1423–1432 (2019) [ doi: 10.1021/acs.molpharmaceut.8b00939 ]
17. Suvarna K, Honda K, Muroi M, Kondoh Y, Osada H, Watanabe N.: A small-molecule ligand of valosin-containing protein/p97 inhibits cancer cell-accelerated fibroblast migration.
    J Biol Chem, 294(9): 2988-2996 (2019) [ doi: 10.1074/jbc.RA118.004741 ]
18. Mikame Y, Yoshida K, Hashizume D, Hirai G, Nagasawa K, Osada H, Sodeoka M.: Synthesis of all stereoisomers of RK460 and evaluation of their activity and selectivity as abscisic acid receptor antagonists.
    Chemistry, 25(14): 3496-3500 (2019) [ doi: 10.1002/chem.201806056 ]
19. Soung NK, Kim HM, Asami Y, Kim DH, Cho Y, Naik R, Jang Y, Jang K, Han HJ, Ganipisetti SR, Cha-Molstad H, Hwang J, Lee KH, Ko SK, Jang JH, Ryoo IJ, Kwon YT, Lee KS, Osada H, Lee K, Kim BY, Ahn JS.: Mechanism of the natural product moracin-O derived MO-460 and its targeting protein hnRNPA2B1 on HIF-1α inhibition.
    Exp Mol Med, 51(2): 10 (2019) [ doi: 10.1038/s12276-018-0200-4 ]
20. Simpkins SW, Deshpande R, Nelson J, Li SC, Piotrowski JS, Ward HN, Yashiroda Y, Osada H, Yoshida M, Boone C, Myers CL.: Using BEAN-counter to quantify genetic interactions from multiplexed barcode sequencing experiments.
    Nat Protoc, 14(2): 415-440 (2019) [ doi: 10.1038/s41596-018-0099-1 ]
21. Motoyama T, Nogawa T, Hayashi T, Hirota H, Osada H.: Induction of nectriapyrone biosynthesis in the rice blast fungus Pyricularia oryzae by disturbance of the two-component signal transduction system.
    Chembiochem, 20(5): 693-700 (2019) [ doi: 10.1002/cbic.201800620 ]
22. Nogawa T, Futamura Y, Okano A, Suto M, Nakamura J, Ishihara K, Osada H.: Construction of a potato fraction library for the investigation of functional secondary metabolites.
    Biosci Biotechnol Biochem, 83(1): 65-75 (2019) [ doi: 10.1080/09168451.2018.1525273 ]
23. Futamura Y, Muroi M, Aono H, Kawatani M, Hayashida M, Sekine T, Nogawa T, Osada H.: Bioenergetic and proteomic profiling to screen small molecule inhibitors that target cancer metabolisms.
    Biochim Biophys Acta, 1867(1): 28–37 (2019) [ doi: 10.1016/j.bbapap.2018.06.001 ]