Assays for cell growth and differentiation. (1) Screening of cell cycle inhibitors by a bioassay using a mouse cdc2 mutant cell line, tsFT210. ⇒Details (2) Screening of inhibitors of mitogenic activity of EGF. ⇒Details
Assays for cell differentiation. (1) Screening for inducer of cell differentiation using HL60 cells. ⇒Details (2) Screening for neutrophic factors and inhibitors of NGF using PC-12 or SH-SY5Y cells. ⇒Details (3) Screening of compounds which repress NGF-induced differentiation of PC-12 cells. ⇒Details (4) Screening for inducer of K-562 cell differentiation. ⇒Details (5) Screening for inhibitors of bone formation using C3H10T1/2 cells, and MC3T3E1 cells. ⇒Details
Assays for cell morphological transformation. (1) Screening for compounds with morphological reversion activity on transformed cells. ⇒Details (2) The bleb forming assay for the activators and inhibitors of PKC. ⇒Details
Assays using microbial cells.
Molecular targeting assay (1) Screening for HIV-1 Vpr inhibitors. ⇒Details (2) Screening for p38 MAP kinase inhibitors. ⇒Details
Assays using morphological response of microbial cell. (1) Screening of antifungal agents through the morphological changes in rice blast fungi.⇒Details
In vitro assays.
Assays for protein functions. (1) Screening for inhibitors or activators of MAP kinases. ⇒Details (2) Screening for heparanase inhibitors. ⇒Details (3) Screening for inhibitors of PDI. ⇒Details (4) Screening for tyrosine phosphatase inhibitors. ⇒Details
Assays for protein-protein interactions. (1) Screening for PBD-dependent binding inhibitors. ⇒Details
Assays for interaction mechanisms between proteins and small molecules. (1) SPR imaging of photo-cross-linked small molecule microarrays on gold. ⇒Details (2) Identification of target proteins using small molecule affinity matrix. ⇒Details
Omics assays.
Genome-wide screening by chemical array technology. ⇒Details
Drug target analysis based on proteomic analysis by 2D-DIGE. (ChemProteoBase) ⇒Details
