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遺伝子資源を化合物資源へ－生合成遺伝子の異種発現による安定生産で実現－

2020-12-15

Nogawa T, Terai A, Amagai K, Hashimoto J, Futamura Y, Okano A, Fujie M, Satoh N, Ikeda H, Shin-Ya K, Osada H, Takahashi S.: Heterologous expression of the biosynthetic gene cluster for verticilactam and identification of analogues.
J Nat Prod, [Epub ahead of print] (2020) [ doi: 10.1021/acs.jnatprod.0c00755 ]
機能低下したミトコンドリアを活性化させる化合物－解糖系酵素ホスホフルクトキナーゼ阻害剤とその新活性の発見－

2020-11-10

Kobayashi H, Hatakeyama H, Nishimura H, Yokota M, Suzuki S, Tomabechi Y, Shirouzu M, Osada H, Mimaki M, Goto YI, Yoshida M.: Chemical reversal of abnormalities in cells carrying mitochondrial DNA mutations.
Nat Chem Biol, [Epub ahead of print] (2020) [ doi: 10.1038/s41589-020-00676-4 ]
かび毒を作るメカニズム－テヌアゾン酸生合成酵素の立体構造解明に成功－

2020-10-27

Yun CS, Nishimoto K, Motoyama T, Shimizu T, Hino T, Dohmae N, Nagano S, Osada H.: Unique features of the ketosynthase domain in a non-ribosomal peptide synthetase-polyketide synthase hybrid enzyme, tenuazonic acid synthetase 1.
J Biol Chem, 295(33): 11602-11612 (2020) [ doi: 10.1074/jbc.RA120.013105 ]
天然化合物の生産を増強する小分子－二次代謝物生産を増強するβカルボリン作用機構の解明－

2020-09-11

Panthee S, Kito N, Hayashi T, Shimizu T, Ishikawa J, Hamamoto H, Osada H, Takahashi S.: β-carboline chemical signals induce reveromycin production through a LuxR family regulator in Streptomyces sp. SN-593.
Sci Rep, 10(1): 10230 (2020) [ doi: 10.1038/s41598-020-66974-y ]
農薬が害虫だけでなく有機汚染物質からも作物を守る ― ウリ科作物で実証 ―

2020-07-18

Fujita K, Kondoh Y, Honda K, Haga Y, Osada H, Matsumura C, Inui H.: Pesticide treatment reduces hydrophobic pollutant contamination in Cucurbita pepo through competitive binding to major latex-like proteins.
Environ Pollut, (2020) in press [ doi: 10.1016/j.envpol.2020.115179 ]
植物の耐塩性を強化する化合物を新たに発見－農作物を塩害に強くする肥料や農薬の開発に貢献－

2020-05-26

Sako K, Futamura Y, Shimizu T, Matsui A, Hirano H, Kondoh Y, Muroi M, Aono H, Tanaka M, Honda K, Shimizu K, Kawatani M, Nakano T, Osada H, Noguchi K, Seki M.: Inhibition of mitochondrial complex I by the novel compound FSL0260 enhances high salinity-stress tolerance in Arabidopsis thaliana.
Sci Rep, 10(1): 8691 (2020) [ doi: 10.1038/s41598-020-65614-9 ]
化合物と結合する標的タンパク質の網羅的解析法を構築

2019-12-05

Nagasawa I, Muroi M, Kawatani M, Ohishi T, Ohba S, Kawada K, Osada H.: Identification of a small compound targeting PKM2-regulated signaling using 2D gel electrophoresis-based proteome-wide CETSA.
Cell Chem Biol, (2019) in press [ doi: 10.1016/j.chembiol.2019.11.010 ]
オカラミンの化学構造と殺虫活性の関係－生合成研究により解明された殺虫活性に必須な部分構造－

2018-05-25

Kato N, Furutani S, Otaka J, Noguchi A, Kinugasa K, Kai K, Hayashi H, Ihara M, Takahashi S, Matsuda K, Osada H.: Biosynthesis and structure-activity relationship studies of okaramines that target insect glutamate-gated chloride channels.
ACS Chem Biol, 13(3): 561-566 (2018) [ doi: 10.1021/acschembio.7b00878 ]
放線菌を用いたボツリオコッセン生産－テルペノイド生産プラットフォームの開発－

2017-12-12

Khalid A, Takagi H, Panthee S, Muroi M, Chappell J, Osada H & Takahashi S.: Development of a Terpenoid-Production Platform in Streptomyces reveromyceticus SN-593.
ACS Synthetic Biology, (2017) [ doi: 10.1021/acssynbio.7b00249 ]
A novel blood glucose–lowering compound

2017-09-15

Enomoto R, Kurosawa A, Nikaido Y, Mashiko M, Saheki T, Nakajima N, Kuroiwa S, Otobe M, Ohsaki M, Tooyama K, Inoue Y, Kuwabara N, Kikuchi O, Kitamura T, Kojima I, Nakagawa Y, Saito T, Osada H, Futahashi M, Sezutsu H, Takeda S.: A novel partial agonist of GPBA reduces blood glucose level in a murine glucose tolerance test.
Eur J Pharmacol, 814([object Object]): 130-137 (2017) [ doi: 10.1016/j.ejphar.2017.08.017 ]
A protein that helps plant cell elongation

2017-01-18

Yamagami A, Saito C, Nakazawa M, Fujioka S, Uemura T, Matsui M, Sakuta M, Shinozaki K, Osada H, Nakano A, Asami T, Nakano T.: Evolutionarily conserved BIL4 suppresses the degradation of brassinosteroid receptor BRI1 and regulates cell elongation.
Sci Rep, 7(1): 5739 (2017) [ doi: 10.1038/s41598-017-06016-2 ]
Opposing roles for SNAP23 in secretion in exocrine and endocrine pancreatic cells

2016-10-03

Kunii M, Ohara-Imaizumi M, Takahashi N, Kobayashi M, Kawakami R, Kondoh Y, Shimizu T, Simizu S, Lin B, Nunomura K, Aoyagi K, Ohno M, Ohmuraya M, Sato T, Yoshimura SI, Sato K, Harada R, Kim YJ, Osada H, Nemoto T, Kasai H, Kitamura T, Nagamatsu S, Harada A.: Opposing roles for SNAP23 in secretion in exocrine and endocrine pancreatic cells.
J Cell Biol, 215(1): 121-138 (2016) [ doi: 10.1083/jcb.201604030 ]
Blue light–specific elongation compound in plants identified

2016-12-14

Ong WD, Okubo-Kurihara E, Kurihara Y, Shimada S, Makita Y, Kawashima M, Honda K, Kondoh Y, Watanabe N, Osada H, Cutler SR, Sudesh K, Matsui M.: Chemical-Induced Inhibition of Blue Light-Mediated Seedling Development Caused by Disruption of Upstream Signal Transduction Involving Cryptochromes in Arabidopsis thaliana.
Plant Cell Physiol, 58 (1): 95-105 (2017) [ doi: 10.1093/pcp/pcw181 ]
Discovery of Streptomyces secondary metabolite pathway mediated by amino-group carrier proteins

2016-09-26

Hasebe F, Matsuda K, Shiraishi T, Futamura Y, Nakano T, Tomita T, Ishigami K, Taka H, Mineki R, Fujimura T, Osada H, Kuzuyama T, Nishiyama T
Amino group carrier protein-mediated secondary metabolite biosynthesis in Streptomyces
Nat Chem Biol , 12: 967–972 (2016) [ doi: 10.1038/nchembio.2181 ]
A new sesquiterpene biosynthesis gene

2016-09-26

Shinohara Y, Takahashi S, Osada H, Koyama Y.: Identification of a novel sesquiterpene biosynthetic machinery involved in astellolide biosynthesis.
Sci Rep, 6: 32865 (2016) [ doi: 10.1038/srep32865 ]
Novel abscisic acid antagonists identified

2015-10-30

Ito T, Kondoh Y, Yoshida K, Umezawa T, Shimizu T, Shinozaki K, Osada H.: Novel Abscisic Acid Antagonists Identified with Chemical Array Screening.
Chembiochem, 16(17): 2471-2478 (2015) [ doi: 10.1002/cbic.201500429 ]
Novel oxylipins modulate amino acid uptake in fission yeast

2016-02-26

Sun X, Hirai G, Ueki M, Hirota H, Wang Q, Hongo Y, Nakamura T, Hitora Y, Takahashi H, Sodeoka M, Osada H, Hamamoto M, Yoshida M, Yashiroda Y.: Identification of novel secreted fatty acids that regulate nitrogen catabolite repression in fission yeast.
Sci Rep, 6: 20856 (2016) [ doi: 10.1038/srep20856 ]
Secrets of a rice-killing fungal toxin

2015-10-27

Yun CS, Motoyama T, Osada H.: Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS-PKS hybrid enzyme.
Nat Commun, 6: 8758 (2015) [ doi: 10.1038/ncomms9758 ]
New enzyme gene required for the formation of specific configurations of microbial secondary metabolites

2015-04-28

Kato N, Nogawa T, Hirota H, Jang JH, Takahashi S, Ahn JS, Osada H.: A new enzyme involved in the control of the stereochemistry in the decalin formation during equisetin biosynthesis.
Biochem Biophys Res Commun, 460(2): 210-215 (2015) [ doi: 10.1016/j.bbrc.2015.03.011 ]
Revealing the workings of a master switch for plant growth

2015-02-07

Shimada S, Komatsu T, Yamagami A, Nakazawa M, Matsui M, Kawaide H, Natsume M, Osada H, Asami T, Nakano T.: Formation and dissociation of the BSS1 protein complex regulates plant development via brassinosteroid signaling.
Plant Cell, 27(2): 375-390 (2015) [ doi: 10.1105/tpc.114.131508 ]
Small-molecule inhibitor uncovers protein role in melanoma cell migration

2010-08-16

Miyazaki I, Simizu S, Okumura H, Takagi S, Osada H.: A small-molecule inhibitor shows that pirin regulates migration of melanoma cells.
Nat Chem Biol, 6(9): 667-673 (2010) [ doi: 10.1038/nchembio.423 ]
Finding the needle in the proteomic haystack

2010-05-28

Muroi M, Kazami S, Noda K, Kondo H, Takayama H, Kawatani M, Usui T, Osada H.: Application of proteomic profiling based on 2D-DIGE for classification of compounds according to the mechanism of action.
Chem Biol, 17(5): 460-470 (2010) [ doi: 10.1016/j.chembiol.2010.03.016 ]

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