Chemical Biology Research Group was closed
Chemical Biology Research Group
RIKEN-Max Planck Joint Research Division for Systems Chemical Biology
Bioprobe Research Group
Bioprobe Application Research Unit
were closed on March 31st in 2022
Recent News
Work at RIKEN: a short introductory video
One of the members of our research group is on this video.
Full version is also uploaded to the RIKEN Global Communications Team's blog. 
the 5th RIKEN-MPG Joint Symposium on Chemical Biology
From April 17 to 20, the 5th RIKEN-MPG Joint Symposium on Chemical Biology was held at the Harnack-Haus, the Max Planck Society’s seminar facility in Berlin.
Novel abscisic acid antagonists identified
We have identified two novel antagonistic compounds for the plant hormone abscisic acid (ABA), RK438 and RK460. The compounds were found in a high-throughput screening of over 24,000 compounds from the RIKEN Natural Products Depository (NPDepo) library, using a chemical array technology which had been developed by the same research group. In this study, small molecules that interact with Arabidopsis ABA receptor PYR1 (pyrabactin resistance 1) were identified with chemical array screening. Further screening narrowed down hit compounds to two molecules, RK438 and RK460. Detailed analysis of RK460 revealed that this compound act antagonistically to certain ABA receptors.
In addition to the discovery of new compounds that could lead to the elucidation of plant hormone signaling pathway, this study encourages the further application of chemical arrays in plant science.
Related
- Press release
- Novel abscisic acid antagonists identified
- Original article
- Ito T, Kondoh Y, Yoshida K, Umezawa T, Shimizu T, Shinozaki K, Osada H.: Novel Abscisic Acid Antagonists Identified with Chemical Array Screening.
Chembiochem, 16(17): 2471-2478 (2015)
[ doi: 10.1002/cbic.201500429 ]
Secrets of a rice-killing fungal toxin
We have discovered the enzyme needed for synthesis of tenuazonic acid (TeA), a well-known toxin that is produced by multiple types of fungus and affects fruits, vegetables, rice, and other crops. In their study published in Nature Communications, the authors describe how they found the gene for this enzyme, and reveal that its structure is unique among known enzymes.
Related
- Press release
- Secrets of a rice-killing fungal toxin
- Original article
- Yun CS, Motoyama T, Osada H.: Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS-PKS hybrid enzyme.
Nat Commun, 6: 8758 (2015) [ doi: 10.1038/ncomms9758 ]
RIKEN-Academia Sinica Joint Conference on Chemical Biology 開催
2015年10月15日から16日の2日間、台湾の中央研究院において、「RIKEN-Academia Sinica Joint Conference on Chemical Biology」が開催されました。2013年に続き、今回がケミカルバイオロジー分野における2回目の合同カンファレンスとなりました。
当グループからは、長田 裕之 副センター長（環境資源科学研究センター）, 渡邉 信元 ユニットリーダー(生理活性物質探索研究ユニット), 近藤 恭光 副基盤ユニットリーダー（創薬ケミカルバンク基盤ユニット）の3名が参加し、それぞれ発表をおこないました。
- Hiroyuki Osada
Screening of Antimicrobial Agents in NPDepo - Nobumoto Watanabe
Cell Cycle Arrest with Small Molecule Inhibitors of Phosohorylation Dependent Protein-protein Interaction - Yasumitsu Kondoh
Chemical Array for Screening of Inhibitors
関連リンク
RIKEN-KRIBB Chemical Biology Joint Symposium
RIKEN-Max Planck Joint Research Center for Systems Chemical Biology - The 4th Symposium
集合写真
関連リンク
医薬品・農薬候補の微生物の代謝物 生成を解明
当研究グループと韓国生命工学院の研究チームの共同研究の成果について、日刊工業新聞に記事が掲載されました。
- 日刊工業新聞 2015年 5月 5日 朝刊 9面
- 「理研など、医薬品・農薬候補物質となる微生物の代謝物の生成メカニズム解明」
関連
- プレスリリース (2015-4-28)
- 微生物が特定の形の代謝物を作るために必要な酵素遺伝子を発見
- 論文
- Kato N, Nogawa T, Hirota H, Jang JH, Takahashi S, Ahn JS, Osada H.: A new enzyme involved in the control of the stereochemistry in the decalin formation during equisetin biosynthesis.
Biochem Biophys Res Commun, [Epub ahead of print] (2015) [ doi: 10.1016/j.bbrc.2015.03.011 ]
The RIKEN Center for Sustainable Resource Science (CSRS) has been founded
The RIKEN Center for Sustainable Resource Science (CSRS) has been founded.
The challenge of the CSRS is to achieve a resource and energy sustainable society through the fusion of different fields, such as biology, chemistry and chemical biology.
We, Chemical Biology Research Group continue to carry out Sustainable Resource Science and chemical biology research as a member of CSRS.