Watabe M, Kakeya H, Osada H.: Requirement of protein kinase (Krs/MST) activation for MT-21-induced apoptosis. Oncogene, 18(37): 5211-5220 (1999) [ doi: 10.1038/sj.onc.1202901 ]
Kakeya H, Morishita M, Koshino H, Morita T, Kobayashi K, Osada H.: Cytoxazone: a novel cytokine modulator containing a 2-oxazolidinone ring produced by Streptomyces sp. J Org Chem, 64(3): 1052-1053 (1999) [ doi: 10.1021/jo981922b ]
Kondoh M, Usui T, Nishikiori T, Mayumi T, Osada H.: Apoptosis induction via microtubule disassembly by an antitumour compound, pironetin. Biochem J, 340 (2): 411-416 (1999) [ doi: 10.1042/bj3400411b ]
Kagamizono T, Hamaguchi T, Ando T, Sugawara K, Adachi T, Osada H.: Phosphatoquinones A and B, novel tyrosine phosphatase inhibitors produced by Streptomyces sp. J Antibiot, 52(2): 75-80 (1999) [ doi: 10.7164/antibiotics.52.75 ]
Usui T, Marriott G, Inagaki M, Swarup G, Osada H.: Protein phosphatase 2A inhibitors, phoslactomycins. Effects on the cytoskeleton in NIH/3T3 cells. J Biochem, 125(5): 960-965 (1999) [ doi: 10.1093/oxfordjournals.jbchem.a022375 ]
Togashi K, Kakeya H, Morishita M, Song YX, Osada H.: Inhibition of human telomerase activity by alterperylenol. Oncol Res, 10(9): 449-453 (1998)
Kimura K, Ikeda Y, Kagami S, Yoshihama M, Suzuki K, Osada H, Isono K.: Selective inhibition of the bacterial peptidoglycan biosynthesis by the new types of liposidomycins. J Antibiot, 51(12): 1099-1104 (1998) [ doi: 10.7164/antibiotics.51.1099 ]
Uchida K, Watanabe H, Usui T, Osada H, Kitahara T. :Syntheses and bioactivities of acetophthalidin and its derivatives. Heterocycles , 48, 2049-2060 (1998) [ doi: 10.3987/COM-98-8246 ]
Kakeya H, Morishita M, Ikeno A, Kobinata K, Yano T, Osada H.: Factumycin and its new derivative RK-1009 enhance threonine-phosphorylation of a 60-kDa protein in Streptomyces griseus. J Antibiot, 51(10): 963-966 (1998) [ doi: 10.7164/antibiotics.51.963 ]
Kakeya H, Onose R, Osada H.: Caspase-mediated activation of a 36-kDa myelin basic protein kinase during anticancer drug-induced apoptosis. Cancer Res, 58(21): 4888-4894 (1998) [ url ]
Kondoh M, Usui T, Mayumi T, Osada H.: Effects of tryprostatin derivatives on microtubule assembly in vitro and in situ. J Antibiot, 51(8): 801-804 (1998) [ doi: 10.7164/antibiotics.51.801 ]
Kakeya H, Onose R, Liu PC, Onozawa C, Matsumura F, Osada H.: Inhibition of cyclin D1 expression and phosphorylation of retinoblastoma protein by phosmidosine, a nucleotide antibiotic. Cancer Res, 58(4): 704-710 (1998) [ url ]
Kakeya H, Morishita M, Kobinata K, Osono M, Ishizuka M, Osada H.: Isolation and biological activity of a novel cytokine modulator, cytoxazone. J Antibiot, 51(12): 1126-1128 (1998) [ doi: 10.7164/antibiotics.51.1126 ]
Kimura K, Kagami S, Ikeda Y, Takahashi H, Yoshihama M, Kusakabe H, Osada H, Isono K.: New types of liposidomycins that inhibit bacterial peptidoglycan synthesis and are produced by Streptomyces. I. Producing organism and medium components. J Antibiot, 51(7): 640-646 (1998) [ doi: 10.7164/antibiotics.51.640 ]
Kimura K, Ikeda Y, Kagami S, Yoshihama M, Ubukata M, Esumi Y, Osada H, Isono K.: New types of liposidomycins that inhibit bacterial peptidoglycan synthesis and are produced by Streptomyces. II. Isolation and structure elucidation. J Antibiot, 51(7): 647-654 (1998) [ doi: 10.7164/antibiotics.51.647 ]
Zhang, HP, Kakeya H, Osada H.:Biosynthesis of 1-aminocyclopropane-1-carboxylic acid moiety on cytotrienin A in Streptomyces sp. Tetrahedron Lett. , 39, 6947-6948 (1998) [ url ]
Usui T, Kondoh M, Cui CB, Mayumi T, Osada H.: Tryprostatin A, a specific and novel inhibitor of microtubule assembly. Biochem J, 333 ( Pt 3)([object Object]): 543-548 (1998) [ doi: 10.1042/bj3330543 ]
Kondoh M, Usui T, Kobayashi S, Tsuchiya K, Nishikawa K, Nishikiori T, Mayumi T, Osada H.: Cell cycle arrest and antitumor activity of pironetin and its derivatives. Cancer Lett, 126(1): 29-32 (1998) [ doi: 10.1016/s0304-3835(97)00528-4 ]
Kakeya H, Zhang HP, Kobinata K, Onose R, Onozawa C, Kudo T, Osada H.: Cytotrienin A, a novel apoptosis inducer in human leukemia HL-60 cells. J Antibiot, 50(4): 370-372 (1997) [ doi: 10.7164/antibiotics.50.370 ]
Zhang H, Kakeya H, Osada H.: Novel triene-ansamycins, cytotrienins A and B, inducing apoptosis on human leukemia HL-60 cells. Tetrahedron Lett. , 38, 1789-1792 (1997) [ url ]
Takahashi H, Yamashita Y, Takaoka H, Nakamura J, Yoshihama M, Osada H.: Inhibitory action of reveromycin A on TGF-alpha-dependent growth of ovarian carcinoma BG-1 in vitro and in vivo. Oncol Res, 9(1): 7-11 (1997)
Hamaguchi T, Masuda A, Morino T, Osada H.: Stevastelins, a novel group of immunosuppressants, inhibit dual-specificity protein phosphatases. Chem Biol, 4(4): 279-286 (1997) [ doi: 10.1016/s1074-5521(97)90071-5 ]
Matsumura F, Enan E, Dunlap DY, Wu Z, Osada, H.: Absence of selected signs of toxicity from TCDD-treated, c-src deficient mice. Organohalogen Compounds , 34, 292-295 (1997)
Kakeya H, Morishita M, Onozawa C, Usami R, Horikoshi K, Kimura K, Yoshihama M, Osada H.: RKS-1778, a new mammalian cell-cycle inhibitor and a key intermediate of the [11]cytochalasin group. J Nat Prod, 60(7): 669-672 (1997) [ doi: 10.1021/np970151o ]
Yagi M, Kato S, Kobayashi Y, Kubo K, Oyama S, Shimizu T, Nishitoba T, Isoe T, Nakamura K, Ohashi H, Kobayashi N, Iinuma N, Osawa T, Onose R, Osada H.: Selective inhibition of platelet-derived growth factor (PDGF) receptor autophosphorylation and PDGF-mediated cellular events by a quinoline derivative. Exp Cell Res, 234(2): 285-292 (1997) [ doi: 10.1006/excr.1997.3616 ]
Muroi M, Kimura K, Osada H, Inukai M, Takatsuki A.: Liposidomycin B inhibits in vitro formation of polyprenyl (pyro)phosphate N-acetylglucosamine, an intermediate in glycoconjugate biosynthesis. J Antibiot, 50(1): 103-104 (1997) [ doi: 10.7164/antibiotics.50.103 ]
Cui CB, Kakeya H, Osada H.: Novel mammalian cell cycle inhibitors, cyclotryprostatins A-D, produced by Aspergillus fumigatus, which inhibit mammalian cell cycle at G2/M Phase. Tetrahedron, 53, 59-72 (1997) [ url ]
Yao R, Yoshihara M, Osada H.: Specific activation of a c-Jun NH2-terminal kinase isoform and induction of neurite outgrowth in PC-12 cells by staurosporine. J Biol Chem, 272(29): 18261-18266 (1997) [ doi: 10.1074/jbc.272.29.18261 ]
Kagamizono T, Sakai N, Arai K, Kobinata K, Osada, H.: Terpeptin, A novel mammalian cell cycle inhibitor, produced by Aspergillus terreus 95F-1. Tetrahedron Lett. , 38, 1223-1226 (1997) [ url ]
Yao R, Osada H.: Induction of neurite outgrowth in PC12 cells by gamma-lactam-related compounds via Ras-MAP kinase signaling pathway independent mechanism. Exp Cell Res, 234(2): 233-239 (1997) [ doi: 10.1006/excr.1997.3615 ]
Kakeya H, Onozawa C, Sato M, Arai K, Osada H.: Neuritogenic effect of epolactaene derivatives on human neuroblastoma cells which lack high-affinity nerve growth factor receptors. J Med Chem, 40(4): 391-394 (1997) [ doi: 10.1021/jm960719a ]
Osada H, Cui CB, Onose R, Hanaoka F.: Screening of cell cycle inhibitors from microbial metabolites by a bioassay using a mouse cdc2 mutant cell line, tsFT210. Bioorg Med Chem, 5(1): 193-203 (1997) [ doi: 10.1016/s0968-0896(96)00207-6 ]
Ubukata M, Morita T, Kakeya H, Kobinata K, Kudo T, Osada H.: Sparoxomycins A1 and A2, new inducers of the flat reversion of NRK cells transformed by temperature sensitive Rous sarcoma virus. I. Taxonomy of the producing organism, fermentation and biological activity. J Antibiot, 49(11): 1096-1100 (1996) [ doi: 10.7164/antibiotics.49.1096 ]
Ubukata M, Morita TI, Uramoto M, Osada H.: Sparoxomycins A1 and A2, new inducers of the flat reversion of NRK cells transformed by temperature sensitive Rous sarcoma virus. II. Isolation, physico-chemical properties and structure elucidation. J Antibiot, 49(1): 65-70 (1996) [ doi: 10.7164/antibiotics.49.65 ]
Shimizu T, Kobayashi R, Osako K, Osada H, Nakata, T.: Synthetic studies on reveromycin A, stereoselective synthsis of the spiroketal system. Tetrahedron Lett. , 37, 6755-6758 (1996) [ url ]
Cui CB, Kakeya H, Osada, H.: Novel mammalian cell cycle inhibitors, spirotryprostatins A and B, produced by Aspergillus fumigatus, which inhibit mammalian cell cycle at G2/M Phase. Tetrahedron , 52, 12651-12666 (1996) [ url ]
Sodeoka M, Sampe R, Kagamizono T, Osada, H.: Asymmetric synthesis of RK-682 and its analogs, and evaluation of their protein phosphatase inhibitory activities. Tetrahedron Lett. , 37, 8775-8778 (1996) [ url ]
Sudo T, Shinohara K, Dohmae N, Takio K, Usami R, Horikoshi K, Osada H.: Isolation and characterization of the gene encoding an aminopeptidase involved in the selective toxicity of ascamycin toward Xanthomonas campestris pv. citri. Biochem J, 319 ( Pt 1)([object Object]): 99-102 (1996) [ doi: 10.1042/bj3190099 ]
Cui Z, Hirata D, Tsuchiya E, Osada H, Miyakawa T.: The multidrug resistance-associated protein (MRP) subfamily (Yrs1/Yor1) of Saccharomyces cerevisiae is important for the tolerance to a broad range of organic anions. J Biol Chem, 271(25): 14712-14716 (1996) [ doi: 10.1074/jbc.271.25.14712 ]
Cui CB, Kakeya H, Osada H.: Spirotryprostatin B, a novel mammalian cell cycle inhibitor produced by Aspergillus fumigatus. J Antibiot, 49(8): 832-835 (1996) [ doi: 10.7164/antibiotics.49.832 ]
Cui CB, Kakeya H, Okada G, Onose R, Osada H.: Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. I. Taxonomy, fermentation, isolation and biological properties. J Antibiot, 49(6): 527-533 (1996) [ doi: 10.7164/antibiotics.49.527 ]
Cui CB, Kakeya H, Osada H.: Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. II. Physico-chemical properties and structures. J Antibiot, 49(6): 534-540 (1996) [ doi: 10.7164/antibiotics.49.534 ]
Isogai Y, Tsuyama T, Osada H, Iizuka T, Tanaka K.: Direct measurement of oscillatory generation of superoxide anions by single phagocytes. FEBS Lett, 380(3): 263-266 (1996) [ doi: 10.1016/0014-5793(96)00068-3 ]
Nishiyama U, Ubukata M, Magae J, Kataoka T, Erdödi F, Hartshorne DJ, Isono K, Nagai K, Osada H.: Structure-activity relationship within a series of degradation products of tautomycin. Biosci Biotechnol Biochem, 60(1): 103-107 (1996) [ doi: 10.1271/bbb.60.103 ]
Matsuura N, Onose R, Osada H.: Morphology reversion activity of phosmidosine and phosmidosine B, a newly isolated derivative, on src transformed NRK cells. J Antibiot, 49(4): 361-365 (1996) [ doi: 10.7164/antibiotics.49.361 ]
Cui CB, Ubukata M, Kakeya H, Onose R, Okada G, Takahashi I, Isono K, Osada H.: Acetophthalidin, a novel inhibitor of mammalian cell cycle, produced by a fungus isolated from a sea sediment. J Antibiot, 49(2): 216-219 (1996) [ doi: 10.7164/antibiotics.49.216 ]
Cui CB, Kakeya H, Okada G, Onose R, Ubukata M, Takahashi I, Isono K, Osada H.: Tryprostatins A and B, novel mammalian cell cycle inhibitors produced by Aspergillus fumigatus. J Antibiot, 48(11): 1382-1384 (1995) [ doi: 10.7164/antibiotics.48.1382 ]
Rani B, Cui CB, Ubukata M, Osada H.: Thiazoline analogues of epiderstatin, new inhibitors of cell cycle of tsFT-210 cells. J Antibiot, 48(10): 1179-1181 (1995) [ doi: 10.7164/antibiotics.48.1179 ]
Ubukata M, Rani BR, Cui CB, Osada H.: Preparation of optically active epiderstatin and its stereoisomers--epiderstatin is not a real inhibitor of the mitogenic activity induced by epidermal growth factor. J Antibiot, 48(10): 1176-1178 (1995) [ doi: 10.7164/antibiotics.48.1176 ]
Ubukata M, Shiraishi N, Kobinata K, Kudo T, Yamaguchi I, Osada H, Shen YC, Isono K.: RS-22A, B and C: new macrolide antibiotics from Streptomyces violaceusniger. I. Taxonomy, fermentation, isolation and biological activities. J Antibiot, 48(4): 289-292 (1995) [ doi: 10.7164/antibiotics.48.289 ]
Ubukata M, Morita T, Osada H.: RS-22A, B and C: new macrolide antibiotics from Streptomyces violaceusniger. II. Physico-chemical properties and structure elucidation. J Antibiot, 48(4): 293-299 (1995) [ doi: 10.7164/antibiotics.48.293 ]
Kakeya H, Takahashi I, Okada G, Isono K, Osada H.: Epolactaene, a novel neuritogenic compound in human neuroblastoma cells, produced by a marine fungus. J Antibiot, 48(7): 733-735 (1995) [ doi: 10.7164/antibiotics.48.733 ]
Koshino S, Koshino H, Matsuura N, Kobinata K, Onose R, Isono K, Osada H.: A new cyclic lipopeptide antibiotic, enamidonin. J Antibiot, 48(2): 185-187 (1995) [ doi: 10.7164/antibiotics.48.185 ]
Fujii S, Kato H, Furuse H, Ito K, Osada H, Hamaguchi T, Kuroda Y.: The mechanism of ATP-induced long-term potentiation involves extracellular phosphorylation of membrane proteins in guinea-pig hippocampal CA1 neurons. Neurosci Lett, 187(2): 130-132 (1995) [ doi: 10.1016/0304-3940(95)11347-9 ]
Fujii S, Ito K, Osada H, Hamaguchi T, Kuroda Y, Kato H.: Extracellular phosphorylation of membrane protein modifies theta burst-induced long-term potentiation in CA1 neurons of guinea-pig hippocampal slices. Neurosci Lett, 187(2): 133-136 (1995) [ doi: 10.1016/0304-3940(95)11342-8 ]
Hamaguchi T, Sudo T, Osada H.: RK-682, a potent inhibitor of tyrosine phosphatase, arrested the mammalian cell cycle progression at G1phase. FEBS Lett, 372(1): 54-58 (1995) [ doi: 10.1016/0014-5793(95)00953-7 ]
Rani BR, Ubukata M, Osada H.: Reduction of arylcarbonyl using zinc dust in acetic acid. Bull. Chem. Soc. Jpn. , 68, 282-284 (1995) [ doi: 10.1246/bcsj.68.282 ]
Ubukata, M, Koshino H, Osada H, Isono K.: Absolute configuration of reveromycin A, an inhibitor of the signal transduction of epidermal growth factor. J. Chem. Soc., Chem. Commun. , 1994, 1877-1878 (1994) [ doi: 10.1039/C39940001877 ]
Osada H, Kikuchi K, Makishima F, Isono K.: Inhibitory action of epiderstatin on EGF-stimulated growth of mouse epidermal. BALB/MK cells without direct effect on protein kinase activities. Oncol Res, 6(1): 11-17 (1994) [ url ]
Ubukata M, Osada H, Kudo T, Isono K.: Respinomycins A1, A2 B, C and D, a novel group of anthracycline antibiotics. I. Taxonomy, fermentation, isolation and biological activities. J Antibiot, 46(6): 936-941 (1993) [ doi: 10.7164/antibiotics.46.936 ]
Ubukata M, Uzawa J, Osada H, Isono K.: Respinomycins A1, A2, B, C and D, a novel group of anthracycline antibiotics. II. Physico-chemical properties and structure elucidation. J Antibiot, 46(6): 942-951 (1993) [ doi: 10.7164/antibiotics.46.942 ]
Suzuki M, Itoh T, Osada H, Rubin JS, Aaronson SA, Suzuki T, Koga N, Saito T, Mitsui Y.: Spleen-derived growth factor, SDGF-3, is identified as keratinocyte growth factor (KGF). FEBS Lett, 328(1-2): 17-20 (1993) [ doi: 10.1016/0014-5793(93)80956-u ]
Koshino H, Kobinata K, Uzawa J, Uramoto M, Isono K, Osada, H.: Structure of malolactomycin A and B, novel 40-membered macrolide antibiotics. Tetrahedron, 49, 8827-8836 (1993) [ url ]
Kobinata K, Koshino H, Kusakabe H, Kobayashi Y, Yamaguchi I, Isono K, Osada H.: Isolation and characterization of a new antibiotic, malolactomycin A. J Antibiot, 46(12): 1912-1915 (1993) [ doi: 10.7164/antibiotics.46.1912 ]
Kobinata K, Koshino H, Kudo T, Isono K, Osada H.: RK-397, a new oxo pentaene antibiotic. J Antibiot, 46(10): 1616-1618 (1993) [ doi: 10.7164/antibiotics.46.1616 ]
Koshino H, Kobinata K, Isono K, Osada H.: Structure of RK-397, a new oxo pentaene antibiotic. J Antibiot, 46(10): 1619-1621 (1993) [ doi: 10.7164/antibiotics.46.1619 ]
Takahashi H, Osada H, Koshino H, Kudo T, Amano S, Shimizu S, Yoshihama M, Isono K.: Reveromycins, new inhibitors of eukaryotic cell growth. I. Producing organism, fermentation, isolation and physico-chemical properties. J Antibiot, 45(9): 1409-1413 (1992) [ doi: 10.7164/antibiotics.45.1409 ]
Takahashi H, Osada H, Koshino H, Sasaki M, Onose R, Nakakoshi M, Yoshihama M, Isono K.: Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activities. J Antibiot, 45(9): 1414-1419 (1992) [ doi: 10.7164/antibiotics.45.1414 ]
Koshino H, Takahashi H, Osada H, Isono K.: Reveromycins, new inhibitors of eukaryotic cell growth. III. Structures of reveromycins A, B, C and D. J Antibiot, 45(9): 1420-1427 (1992) [ doi: 10.7164/antibiotics.45.1420 ]
Koshino H, Osada H, Amano S, Onose R, Isono K.: A new inhibitor of protein kinase C, RK-1409B (4'-demethylamino-4'-hydroxy-3'-epistaurosporine). J Antibiot, 45(9): 1428-1432 (1992) [ doi: 10.7164/antibiotics.45.1428 ]
Osada H, Satake M, Koshino H, Onose R, Isono K.: A new indolocarbazole antibiotic, RK-286D. J Antibiot, 45(2): 278-279 (1992) [ doi: 10.7164/antibiotics.45.278 ]
Osada H, Koshino H, Kudo T, Onose R, Isono K.: A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). I. Taxonomy and biological activity. J Antibiot, 45(2): 189-194 (1992) [ doi: 10.7164/antibiotics.45.189 ]
Koshino H, Osada H, Isono K.: A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). II. Fermentation, isolation, physico-chemical properties and structure. J Antibiot, 45(2): 195-198 (1992) [ doi: 10.7164/antibiotics.45.195 ]
Osada H, Sasaki M, Sonoda T, Isono K.: Epiderstatin induces the flat reversion of NRK cells transformed by temperature-sensitive Rous sarcoma virus. Biosci Biotechnol Biochem, 56(11): 1801-1806 (1992) [ doi: 10.1271/bbb.56.1801 ]
Sonoda T, Kobayashi K, Ubukata M, Osada H, Isono K.: Absolute configuration of epiderstatin, a new glutarimide antibiotic produced by Streptomyces pulveraceus. J Antibiot, 45(12): 1963-1965 (1992) [ doi: 10.7164/antibiotics.45.1963 ]
Osada H, Koshino H, Isono K, Takahashi H, Kawanishi G.: Reveromycin A, a new antibiotic which inhibits the mitogenic activity of epidermal growth factor. J Antibiot, 44(2): 259-261 (1991) [ doi: 10.7164/antibiotics.44.259 ]
Sonoda T, Osada H, Uzawa J, Isono K.: Actiketal, a new member of the glutarimide antibiotics. J Antibiot, 44(2): 160-163 (1991) [ doi: 10.7164/antibiotics.44.160 ]
Osada H, Yano T, Koshino H, Isono K.: Enopeptin A, a novel depsipeptide antibiotic with anti-bacteriophage activity. J Antibiot, 44(12): 1463-1466 (1991) [ doi: 10.7164/antibiotics.44.1463 ]
Koshino H, Osada, H, Yano T, Uzawa J, Isono K.: The structure of enopeptins A and B, novel depsipeptide antibiotics. Tetrahedron Lett. , 32, 7707-7710 (1991) [ url ]
Kobinata K., Sekido S, Uramoto M, Ubukata M, Osada H, Yamaguchi I, Isono K.: Isoxazole-4-carboxylic acid as a metabolite of Streptomyces sp. and its herbicidal activity. Agric. Biol. Chem. , 55, 1415-1416 (1991) [ doi: 10.1271/bbb1961.55.1415 ]
Usui T, Yoshida M, Abe K, Osada H, Isono K, Beppu T.: Uncoupled cell cycle without mitosis induced by a protein kinase inhibitor, K-252a. J Cell Biol, 115(5): 1275-1282 (1991) [ doi: 10.1083/jcb.115.5.1275 ]
Ubukata M, Tanaka C, Osada H, Isono K.: Respinomycin A1, a new anthracycline antibiotic. J Antibiot, 44(11): 1274-1276 (1991) [ doi: 10.7164/antibiotics.44.1274 ]
Magae J, Osada H, Fujiki H, Saido TC, Suzuki K, Nagai K, Yamasaki M, Isono K.: Morphological changes of human myeloid leukemia K-562 cells by a protein phosphatase inhibitor, tautomycin. Proc. Japan Acad. , 66(B),209-212 (1990) [ doi: 10.2183/pjab.66.209 ]
Osada H, Takahashi H, Tsunoda K, Kusakabe H, Isono K.: A new inhibitor of protein kinase C, RK-286C (4'-demethylamino-4'-hydroxystaurosporine). I. Screening, taxonomy, fermentation and biological activity. J Antibiot, 43(2): 163-167 (1990) [ doi: 10.7164/antibiotics.43.163 ]
Takahashi H, Osada H, Uramoto M, Isono K.: A new inhibitor of protein kinase C, RK-286C (4'-demethylamino-4'-hydroxystaurosporine). II. Isolation, physico-chemical properties and structure. J Antibiot, 43(2): 168-173 (1990) [ doi: 10.7164/antibiotics.43.168 ]
Sonoda T, Osada H, Magae J, Isono K.: Epiderstatin and its related glutarimide antibiotics inhibited the cell growth induced by mitogen stimulation. Agric. Biol. Chem. , 54, 1259-1263 (1990) [ doi: 10.1271/bbb1961.54.1259 ]
Osada H, Uramoto M, Uzawa J, Kajikawa K, Isono K.: New pyrrolobenzodiazepine antibiotics, RK-1441A and B. II. Isolation and structure. Agric Biol Chem, 54(11): 2883-2887 (1990) [ doi: 10.1271/bbb1961.54.2883 ]
Osada H, Ishinabe K, Yano T, Kajikawa K, Isono K.: New pyrrolobenzodiazepine antibiotics, RK-1441A and B. I. Biological properties. Agric Biol Chem, 54(11): 2875-2881 (1990)
[ doi: 10.1271/bbb1961.54.2875 ]
Rubin JS, Osada H, Finch PW, Taylor WG, Rudikoff S, Aaronson SA.: Purification and characterization of a newly identified growth factor specific for epithelial cells. Proc Natl Acad Sci U S A, 86(3): 802-806 (1989) [ doi: 10.1073/pnas.86.3.802 ]
Osada H, Sonoda T, Kusakabe H, Isono K.: Epiderstatin, a new inhibitor of the mitogenic activity induced by epidermal growth factor. I. Taxonomy, fermentation, isolation and characterization. J Antibiot, 42(11): 1599-1606 (1989) [ doi: 10.7164/antibiotics.42.1599 ]
Sonoda T, Osada H, Uramoto M, Uzawa J, Isono K.: Epiderstatin, a new inhibitor of the mitogenic activity induced by epidermal growth factor. II. Structure elucidation. J Antibiot, 42(11): 1607-1609 (1989) [ doi: 10.7164/antibiotics.42.1607 ]
Osada H, Sonoda T, Tsunoda K, Isono K.: A new biological role of sangivamycin; inhibition of protein kinases. J Antibiot, 42(1): 102-106 (1989) [ doi: 10.7164/antibiotics.42.102 ]
Magae J, Osada H, Nagai K, Yamasaki M, Isono K.: Comparison of the effect of tautomycin and phorbol ester on protein kinase C in a cell-free system. J Antibiot, 42(8): 1290-1293 (1989) [ doi: 10.7164/antibiotics.42.1290 ]
Cheng XC, Kihara T, Ying X, Uramoto M, Osada H, Kusakabe H, Wang BN, Kobayashi Y, Ko K, Yamaguchi I, Shen YC, Isono K.: A new antibiotic, tautomycetin. J Antibiot, 42(1): 141-144 (1989) [ doi: 10.7164/antibiotics.42.141 ]
Magae J, Watanabe C, Osada H, Cheng XC, Isono K.: Induction of morphological change of human myeloid leukemia and activation of protein kinase C by a novel antibiotic, tautomycin. J Antibiot, 41(7): 932-937 (1988) [ doi: 10.7164/antibiotics.41.932 ]
Osada H, Magae J, Watanabe C, Isono K.: Rapid screening method for inhibitors of protein kinase C. J Antibiot, 41(7): 925-931 (1988) [ doi: 10.7164/antibiotics.41.925 ]
Ubukata M, Osada H, Magae J, Isono K.: Synthesis and biological activity of aminoacyl analogs of ascamycin. Agric. Biol. Chem. , 52, 1117-1122 (1988) [ doi: 10.1271/bbb1961.52.1117 ]
Osada H, Isono K.: Occurrence of an ascamycin dealanylating enzyme, Xc-aminopeptidase, in mammalian cell membranes and susceptibility to ascamycin. J Antibiot, 39(2): 286-293 (1986) [ doi: 10.7164/antibiotics.39.286 ]
Osada H, Isono K.: Purification and characterization of ascamycin-hydrolysing aminopeptidase from Xanthomonas citri. Biochem J, 233(2): 459-463 (1986) [ doi: 10.1042/bj2330459 ]
Osada H, Isono K.: Mechanism of action and selective toxicity of ascamycin, a nucleoside antibiotic. Antimicrob Agents Chemother, 27(2): 230-233 (1985) [ doi: 10.1128/aac.27.2.230 ]
Osada H, Beppu, T.: Lipopolysaccharide defective mutant of Escherichia coli with decreased sensitivity to colicin E2. Agric. Biol. Chem. , 49, 1813-1819 (1985) [ doi: 10.1271/bbb1961.49.1813 ]
[ doi: 10.1038/sj.onc.1202901 ]