2007 Presentation

4th Takeda Science Foundation Symposium on Pharma Sciences On the Frontiers of Chemical Biology

Dec. 10th - 12th, 2007, Tokyo, Japan.

  • Sayaka Kazami, Makoto Muroi, Takeo Usui, Kubota 　 Junichi Kobayashi, Hiroyuki Osada.
    Application of 2D-DIGE for target identification and binding site determination of bioprobes

  • Hideo Okumura, Masashi Ueki, Yoshitsugu Shiro, Hiroyuki Osada.
    Substrate recognition mechanism of NRPS A domain from Streptomyces.

  • Masashi Ueki, Atsushi Toyoda, Yoshiyuki Sasaki, Christopher Walsh, Hiroyuki Osada.
    Biosynthesis of Cytotrienin in Streptomyces sp. RK95-74.

  • Shunji Takahashi, Atsushi Toyoda, Ryuichiro Suzuki, Yasuyo Sekiyama, Masashi Ueki, Tohru Dairi, Jun Ishikawa, Haruo Ikeda, Yoshiyuki Sasaki, Hiroyuki Osada.
    Analysis of reveromycin A biosynthetic gene cluster in Streptomyces reveromyceticus.

  • Isao Miyazaki, Siro Simizu, Harumi Ichimiya, Hiroyuki Osada.
    Establishment of chemical array platform and discovery of novel carbonic anhydrase II ligands.

  • Kayoko Kawai, Akiko Saito, Tatsuhiko Sudo, Hiroyuki Osada.
    Specific regulation of cytokine dependent p38 MAP kinase activation by p62/SQSTM1.

  • Nobumoto Watanabe, Tomomi Sekine, Junichi Iwasaki, Hiroyuki Osada.
    A small molecule which inhibits the polo box domain dependent recognition of PLK1.

HUPO 6th Annual World Congress (HUPO 2007)

Oct., 2007, Seoul, Korea
  • Hiroyuki Osada*
    Systematic exporation of the interaction between bioactive compound and their target proteins.

Chemical Genomics Symposium

Oct., 2007, Seoul, Korea
  • Hiroyuki Osada*
    Chemical biology of osteoclast-targeting small molecules.

2007 AACR-NCI-EORTC International Conference Molecular Targets and Cancer Therapeutics

Oct., 2007, San Francisco, USA.

  • Nobumoto Watanabe, Junichi Iwasaki, Tomomi Sekine, Hiroyuki Osada.
    Small molecule inhibitors for polo box domain dependent recognition.

  • Makoto Kawatani Kaori Honda Naoki Kanoh Makoto Muroi Naoshi Dohmae Masaya Imoto Hiroyuki Osada.
    The identification of a novel inhibitor of osteoclastogenesis that acts via inhibition of glyoxalase I.

  • Siro Simizu Yuki Tamura Makoto Kawatani Nobumoto Watanabe Hiroyuki Osada.
    Phosphorylation of Bcl-xL by polo-like kinase 1 results in the inactivation of the anti-apoptotic activity during tubulin binder-induced apoptosis