Compounds reported from RIKEN (Antibiotics Lab and Chemical Biology Research Group)
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* : re-discovered compounds as new bioactive roles other than previously reported.
Index A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z
| Compound name | Biological activity | Producing organism | Year reported | Details | |
|---|---|---|---|---|---|
| A | acetophthalidin | cell cycle inhibition | Aspergillus sp. | 1996 | ⇒ |
| actiketal | mitogen | Streptomyces pulberaceus subsp. epiderstagenes | 1991 | ⇒ | |
| albopeptin B | antimicrobial | Streptomyces albofaciens | 1986, 92 | ⇒ | |
| ascamycin | antibacterial | Streptomyces sp. | 1984 | ⇒ | |
| azaspirene | antiangiogenesis | Neosartorya sp. | 2002 | ⇒ | |
| B | benzyl-methylcoumarin | p38MAPK inhibitors | (Chemically synthesized) | 2009 | ⇒ |
| C | cationomycin A - D | antimicrobial | Actinomadura azurea | 1981-83 | ⇒ |
| curvularol | cytotoxic | Curvularia sp. | 2001 | ⇒ | |
| cyclotryprostatin A - D | tubulin assemble inhibition | Aspergillus fumigatus | 1995 | ⇒ | |
| cytotrienin A, B | apoptosis-inducing | Streptomyces sp. | 1997 | ⇒ | |
| cytovaricin | cytostatic | Streptomyces sp. | 1981 | ⇒ | |
| cytoxazone | cytokine modulator | Streptomyces sp. | 1998 | ⇒ | |
| D | dephospho-phoslactomycin B | differentiation inducer, enhancer of differentiation potential of all-trans retinoic acid. | Streptomyces sp. | 2009 | ⇒ |
| E | ECH * | Fas-mediated apoptosis inhitibitor | uncharacterized fungus | 2003 | ⇒ |
| enamidonin | flat reversion activity of v-src transformed cells | Streptomyces sp. | 1995 | ⇒ | |
| enopeptin A, B | anti-bacteriophage activity | Streptomyces sp. RK-1051 | 1991 | ⇒ | |
| epiderstatin | anti-mitogenic activity | Streptomyces pulveraceus subsp. epiderstagenes | 1989 | ⇒ | |
| epolactaene | induction of neurite outgrowth | Penicillium sp. | 1995 | ⇒ | |
| epoxyquinol A, B | angiogenic inhibitor | uncharacterized fungus | 2002 | ⇒ | |
| epoxytwinol A | angiogenic inhibitor | uncharacterized fungus | 2005 | ⇒ | |
| F | furaquinocin I, J | (no cytotoxic activity) | Streptomyces reveromyceticus SN-593 | 2011 | ⇒ |
| G | guanine 7-N-oxide | antitumor | Streptomyces sp. | 1985 | ⇒ |
| H | hitoyol A, B | weak anti-malarial activity | Coprinopsis cinerea | 2017 | ⇒ |
| hitoyopodin A, 15-hitoyopodin A, 13-hitoyopodin A |
growth inhibition | Coprinopsis cinerea | 2018 | ⇒ | |
| I | indole-carbaldehyde | (no biological activity reported) | Streptomyces sp. SN-593 | 2010 | ⇒ |
| iso-avenaciolide * | phosphatase inhibitor | Aspergillus sp. | 2002 | ⇒ | |
| isoxazole 4-carboxylate | herbicidal | Streptomyces sp. | 1991 | ⇒ | |
| J | juniferdin * | protein disulfide isomerase inhibitor | Ferula junipernia | 2011 | ⇒ |
| K | kinanthraquinone | moderate cytotoxocity | Streptomyces reveromyceticus SN-593-44 | 2018 | ⇒ |
| L | linearolide A, B | weak cytotoxicity | Streptomyces sp. RK95-74 | 2013 | ⇒ |
| lipopeptin A - C | antimicrobial | Streptomyces sp. | 1980 | ⇒ | |
| liposidomycin B, C | antibacterical, inhibition of peptideglycan synthesis | Streptomyces griseosporeus | 1988-89 | ⇒ | |
| lucilactaene | cell cycle inhibition | Fusarium sp. | 2001 | ⇒ | |
| M | malolactomycin A | antifungal | Streptomyces sp. 83-634 | 1993 | ⇒ |
| methyl gerfelin | glyoxalase I inhibitor | Beauveria felina | 2008, 2013 | ⇒ | |
| metarhizin C | selective cytotoxicity against osteosarcoma MG-63 | Tolypocladium album RK17-F0007 | 2019 | ⇒ | |
| N | neopeptin A - C | inhibition of fungal cell wall synthesis | Streptomyces sp. | 1986 | ⇒ |
| NPD926 | glutathione depletion | (Chemically synthesized) | 2014 | ⇒ | |
| NPD6689 | tubulin inhibitor | (Chemically synthesized) | 2012 | ⇒ | |
| nocardamin glucuronide | siderophore | Streptomyces sp. 80H647 | 2019 | ⇒ | |
| O | opantimycin A | cytotoxicity and antimalarial activity | Streptomyces sp. RK88-1355 | 2016 | ⇒ |
| P | phoslactomycin A - F phosphazomycin C1, C2 | inhibitor of protein phosphatase 2A | Streptomyces sp. | 1985 | ⇒ |
| phosmidosine | antifungal | Streptomyces sp. RK-16 | 1991 | ⇒ | |
| phosphatoquinone A, B | inhibitor of protein tyrosine phosphatase | Streptomyces sp. | 1999 | ⇒ | |
| pironetin * | tubulin disassembler | Streptomyces sp. | 1999 | ⇒ | |
| polyoxin A - M | inhibition on fungal cell-wall synthesis | Streptomyces cacaoi ver. asoensis | 1969-93 | ⇒ | |
| protuboxepin A | microtubule-stabilizing agent | Aspergillus sp. | 2011 | ⇒ | |
| purpurogallin * | inhibitor of Plk1 Polo Box Domain-dependent binding | nutgall | 2009 | ⇒ | |
| pyrrolizilactone | proteasome inhibitor | an uncharacterized fungus | 2013 | ⇒ | |
| Q | questiomycin A, B | antimicrobial | Streptomyces sp. | 1965 | ⇒ |
| R | respinomycin A - D | induction of cell differentiation | Streptomyces xanthocidicus | 1991-93 | ⇒ |
| reveromycin A - D | antifungal, cytotoxic | Streptomyces sp. SN593 | 1990-92 | ⇒ | |
| reveromycin T 1-methyl ester and 1-ethyl ester | cytotoxicity against mammarial cancer cells | Streptomyces reveromyceticus SN-593 | 2013 | ⇒ | |
| RK-286C, D | inhibitor of protein kinase C | Streptomyces sp. RK-286 | 1990 | ⇒ | |
| RK-397 | antifungal | Streptomyces violaceusnigar | 1993 | ⇒ | |
| RK-682 * | phosphatase inhibitor | Streptomyces sp. | 1995 | ⇒ | |
| RK-805 | inhibitor of methionine aminopeptidase 2 | Neosartorya sp. | 2004 | ⇒ | |
| RK-1009 | --- | Streptomyces sp. | 1998 | ⇒ | |
| RK-1355A, B | cytotoxicity, antimicrobial | Streptomyces sp. RK88-1355 | 2014 | ⇒ | |
| RK-1409A, B | inhibitor of protein kinase C | Streptomyces platensis subsp. malvinus RK-1409 | 1992 | ⇒ | |
| RK-1441A, B | antibacteriophage | Streptomyces sp. | 1990 | ⇒ | |
| RK-95113 | antiogenesis inhibitor | Aspergillus fumigatus | 2006 | ⇒ | |
| RS-22A - C | antimicrobial | Streptomyces violaceusnigar | 1995 | ⇒ | |
| S | sangivamycin * | inhibitor of protein kinase C | Streptomyces sp. | 1989 | ⇒ |
| sparoxomycin A1, A2 | flat reversion activity of v-src transformed cells | Streptomyces sparsogenes | 1996 | ⇒ | |
| spirotoamide A, B | (no antibacterial, antifungal, and cytotoxic activities) | Streptomyces griseochromogenes JC82-1223 | 2012 | ⇒ | |
| stevastelin * | phosphatase inhibitor | Aspergillus sp. | 1997 | ⇒ | |
| T | tautomycetin | inhibition of protein phosphatase | Streptomyces sp. | 1989 | ⇒ |
| tautomycin | inhibition of protein phosphatase | Streptomyces sp. | 1987 | ⇒ | |
| terpendole E *, H, C, I | cell cycle inhibition, inhibition of kinesin Eg5 | Albophoma yamashiensis | 2003 | ⇒ | |
| terpeptin | cell cycle inhibition | Aspergillus terreus | 1997 | ⇒ | |
| TPh A | inhibitor of pirin | (Chemically synthesized) | 2010 | ⇒ | |
| trichostatin RK | -- | Streptomyces sp. RK98-A74 | 2001 | ⇒ | |
| tryprostatin A, B demethoxyfumitremorgin C spirotryprostatin B |
tubulin assemble inhibition | Aspergillus fumigatus | 1995 | ⇒ | |
| U | unantimycin A | cytotoxicity and antimalarial activity | Streptomyces sp. RK88-1355 | 2016 | ⇒ |
| V | verticilactam | (no antibacterial, antifungal and cytotoxic activities) | Streptomyces spiroverticillatus JC-8444 | 2010 | ⇒ |
| vipirinin | HIV Vpr inhibitor | (Chemically synthesized) | 2011 | ⇒ | |
| W | wakodecaline A, B | moderate antimalarial activity | Pyrenochaetopsis sp. RK10-F058 | 2017 | ⇒ |
| X | xanthohumol * | valosin-containing protein inhibitor | Humulus lupulus | 2012 | ⇒ |
| xanthostatin | antibacterial | Streptomyces sp. | 1987 | ⇒ | |
| Y | YO-001A | antifungal, inhibition of the FOF1-ATPase activity | Streptomyces sp. YO15-A001 | 2019 | ⇒ |
| Z | zearalenone *, zearalenone cleavage product |
estrogenic activity and detoxification | Fusarium sp, Clonostachys roseal IFO 7063 |
2002 | ⇒ |