ケミカルバイオロジー研究グループ（終了）
Malolactomycin A
- Structure
-
- Producing organism
- Streptomyces sp. 83-634 (Isolated in Okinawa, Japan)
- Biological activity
- antifungal activity
- Abstract
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- References
-
isolation and structural determination
- Kobinata K, Koshino H, Kusakabe H, Kobayashi Y, Yamaguchi I, Isono K, Osada H.: Isolation and characterization of a new antibiotic, malolactomycin A.
J Antibiot, 46(12): 1912-1915 (1993)
related compounds- Tanaka Y, Yoshida H, Enomoto Y, Shiomi K, Shinose M, Takahashi Y, Liu JR, Omura S.: Malolactomycins C and D, new 40-membered macrolides active against Botrytis.
J Antibiot, 50(3): 194-200 (1997)- Futamura M, Kamiya S, Tsukamoto M, Hirano A, Monden Y, Arakawa H, Nishimura S.: Malolactomycin D, a potent inhibitor of transcription controlled by the Ras responsive element, inhibits Ras-mediated transformation activity with suppression of MMP-1 and MMP-9 in NIH3T3 cells.
Oncogene, 20(46): 6724-6730 (2001) [ doi: 10.1038/sj.onc.1204878 ] - Kobinata K, Koshino H, Kusakabe H, Kobayashi Y, Yamaguchi I, Isono K, Osada H.: Isolation and characterization of a new antibiotic, malolactomycin A.