Motoyama T, Yun CS, Osada H.
Biosynthesis and biological function of secondary metabolites of the rice blast fungus Pyricularia oryzae. J Ind Microbiol Biotechnol, 48(9-10): (2021) [ doi: 10.1093/jimb/kuab058 ]
Muroi M, Osada H.
Proteomics-based target identification of natural products affecting cancer metabolism. J Antibiot, 74(10): 639-650 (2021) [ doi: 10.1038/s41429-021-00437-y ]
Lopez JAV, Osada H.
Fraction libraries and genetics as tools for natural product research: focus on decalin-containing compounds. In: Liu HB and Begley TP (eds.) Comprehensive natural products III: chemistry and biology. vol. 7, pp. 375-409, Elsevier, (2020) [ doi: 10.1016/B978-0-12-409547-2.14658-X]
Watanabe N, Osada H.
Small molecule inhibitors of E3 ubiquitin ligases In: Roy S, Fu H (eds.) Protein–protein interaction regulators. Drug discovery series No. 78 pp. 109-123, Royal society of chemistry, (2020) [ doi: 10.1039/9781788016544]
Osada H.
Discovery and applications of nucleoside antibiotics beyond polyoxin. J Antibiot, 72, 853–854 (2019) [ doi: 10.1038/s41429-019-0237-1 ]
Muroi M, Osada H.
Proteomic profiling for target identification of biologically active small molecules using 2D DIGE Systems Chemical Biology (Ziegler S., Waldmann H. eds.): Methods and Protocols, Methods in Molecular Biology, 1888, 127-139 (2019) [ doi: 10.1007/978-1-4939-8891-4_7 ]
Osada H. Trends in bioprobe research. Bioprobes (Ed. H. Osada), Springer, 1-10 (2017) [ doi: 10.1007/978-4-431-56529-1_1 ]
Watanabe N, Osada H. Cell proliferation and differentiation. Bioprobes (Ed. H. Osada), Springer, 11-35 (2017) [ doi: 10.1007/978-4-431-56529-1_2 ]
Motoyama T, Osada H.
Biosynthetic approaches to creating bioactive fungal metabolites: Pathway engineering and activation of secondary metabolism. Bioorg Med Chem Lett, 26(24): 5843-5850 (2016) [ doi: 10.1016/j.bmcl.2016.11.013 ]
Osada H.
Chemical and biological studies of reveromycin A. J Antibiot, 69(10): 723-730 (2016) [ doi: 10.1038/ja.2016.57 ]
Watanabe N, Osada H.
Small molecules that target phosphorylation dependent protein-protein interaction. Bioorg Med Chem, 24(15): 3246-3254 (2016) [ doi: 10.1016/j.bmc.2016.03.023 ]
Muroi M, Futamura Y, Osada H.
Integrated profiling methods for identifying the targets of bioactive compounds: MorphoBase and ChemProteoBase. Nat Prod Rep, 33(5): 621-625 (2016) [ doi: 10.1039/c5np00106d ]
Kondoh Y, Honda K, Osada H.
Construction and application of a photo-cross-linked chemical array. Methods Mol Biol, 1263, 29-41 (2015) [ doi: 10.1007/978-1-4939-2269-7_3 ]
Glickman JF, Lundbäck T, Napper AD, Niles WD, Simeonov A, Weaver CD, Yin HH, Zaman GJ, Osada H.
Controversies in ASSAY and drug development technologies: a focus on assessing irreproducibility. Assay Drug Dev Technol, 12 (8): 443-451 (2014) [ doi: 10.1089/adt.2014.1501 ]
Osada H, Muroi M, Kondoh Y, Futamura Y.
A Target Identification System Based on MorphoBase, ChemProteoBase, and Photo-Cross-Linking Beads Concepts and Case Studies in Chemical Biology (Ed. Waldmann H, Janning P), Wiley-VCH,
163-175 (2014) [ doi: 10.1002/9783527687503.ch11 ]
Kawatani M, Osada H.
Affinity-based target identification for bioactive small molecules. Med. Chem. Commun., 5, 277-287 (2014) [ doi: 10.1039/c3md00276d ]
Wada A, Kato N, Ziegler S.
Joint knowledge and technology for systems chemical biology. Chembiochem, 14 (12): 1504-1506 (2013) [ doi: 10.1002/cbic.201300412 ]
Nakamoto H, Osada H.
Molecular chaperones as drug targets. Curr Pharm Des, 19 (3): 307-308 (2013) [ doi: 10.2174/138161213804143671 ]
Futamura Y, Muroi M, Osada H.
Target identification of small molecules based on chemical biology approaches. Mol Biosyst, 9(5): 897-914 (2013) [ doi: 10.1039/c2mb25468a ]
Kondoh Y, Osada H.
High-throughput screening identifies small molecule inhibitors of molecular chaperones. Curr Pharm Des, 19 (3): 473-492 (2013) [ doi: 10.2174 /138161213804143743 ]
Watanabe N, Osada H.
Phosphorylation-dependent protein-protein interaction modules as potential molecular targets for cancer therapy. Curr Drug Targets, 13 (13): 1654-1658 (2012) [ doi: 10.2174/138945012803530035 ]
Kato N, Takahashi S, Nogawa T, Saito T, Osada H. Construction of a microbial natural product library for chemical biology studies. Curr Opin Chem Biol.,16(1-2): 101-108 (2012) [ doi: 10.1016/j.cbpa.2012.02.016 ]
Osada H, Muroi M, Yoshida M. The chemistry/biology interface. Bioorg Med Chem., 20, 1844-1845 (2012) [ 10.1016/j.bmc.2012.02.053 ]
Wierzba K, Muroi M, Osada H. Proteomics accelerating the identification of the target molecule of bioactive small molecules. Curr Opin Chem Biol, 15: 57-65, (2011) [ doi: 10.1016/j.cbpa.2010.10.009 ]
Miyazaki I, Simizu S, Osada H. The application of the chemical array for biological study. Methods Molec Biol., 669, 95-107, (2010) [ doi: 10.1007/978-1-60761-845-4_8 ]
Osada H, Hertweck C.
Exploring the chemical space of microbial natural products. Curr Opin Chem Biol, 13 (2): 133-134 (2009) [ doi: 10.1016/j.cbpa.2009.03.017 ]
Kawatani M, Osada H.
Osteoclast-targeting small molecules for the treatment of neoplastic bone metastases. Cancer Sci, 100 (11): 1999-2005 (2009) [ doi: 10.1111/j.1349-7006.2009.01294.x ]
Osada, H., Chemical biology based on small molecule-protein interaction. Protein targeting with small molecules; Chemical biology techniques and applications (Ed Osada H.), 1-10 (2009) [ doi: 10.1002/9780470495018.ch4 ]
Kanoh N, Osada H. Recent developments and advances in chemical array. Protein targeting with small molecules; Chemical biology techniques and applications (Ed Osada H.), 57-80 (2009). [ doi: 10.1002/9780470495018.ch4 ]
Usui, T., Saito, A., and Osada, H., Data on small molecules and their target proteins. Protein targeting with small molecules; Chemical biology techniques and applications (Ed Osada H.), 239-276 (2009). [ doi: 10.1002/9780470495018.ch4 ]
Kwon HJ, Lee CH, Osada H, Yoshida M, Imoto M. Hot springs and cool natural products. Nat Chem Biol, 4(8): 444-446 (2008) [ doi: 10.1038/nchembio0808-444 ]
Osada H. The Japanese society for chemical biology. ACS Chemi. Biol., 1, 8 (2006) [ doi: 10.1021/cb0600039 ]
Osada H, Hagiwara M, Toshima K, Imoto M.: The education system for chemical biology in Japanese universities. ACS Chem Biol, 1(8): 492-494 (2006) [ doi: 10.1021/cb6003614 ]
Simizu S, Ishida K, Osada H.: Heparanase as a molecular target of cancer chemotherapy. Cancer Sci, 95(7): 553-558 (2004) [ doi: 10.1111/j.1349-7006.2004.tb02485.x ]
Machida K, Osada H. Molecular interaction between cyclophilin D and adenine nucleotide translocase in cytochrome c release: does it determine whether cytochrome c release is dependent on permeability transition or not? Ann. NY. Acad. Sci., 1010, 182-185 (2003)
Okada K, Taguchi H, Seio K, Kakeya H, Osada H, Sasaki T, Sekine M. Synthesis and biological properties of stable phosmidosine analogs. Nucleic Acids Res. Suppl., 2003, 105-106 (2003)
Osada H. Development and application of bioprobes for mammalian cell cycle analyses. Curr. Med. Chem., 10, 727-732 (2003)
Sudo T, Maruyama M, Osada H. Stress meets development in p38 MAP kinase. Molecular anatomy of cellular systems, 22, 3-11 (2002)
Usui T, Nakazawa J, Osada H. Studies on inhibitory mechanism of microtubule inhibitors. RIKEN Review, 41, 92-93 (2001)
Sudo T, Maruyama M, Yagasaki Y, Osada H. Over the stress responses:Functional analyses of p38alpha. RIKEN Review, 41, 64-66 (2001)
Osada H. An overview on the diversity of actinomycete metabolites. Actinomycetol., 15, 11-14 (2001)
Osada H. Differentiation. Bioprobes (Ed. H. Osada), Springer, 43-65 (2000)
Usui T, Osada H. Bioprobes at a glance. Bioprobes (Ed. H. Osada), Springer, 126-305 (2000)
Osada H. Trends in bioprobe research. Bioprobes (Ed. H. Osada), Springer, 1-14 (2000)
Kakeya H, Onose O, Osada H. Activation of a 36-kD MBP kinase, an active proteolytic fragment of MST/Krs proteins,during anticancer drug-induced apoptosis. Ann. NY. Acad. Sci., 886, 273-275 (1999)
Osada H. Actinomycetes, how fascinating microorganisms. Actinomycetol., 12, 85-88 (1998)
Kagami S, Kimura K, Ikeda Y, Takahashi H, Kusakabe H, Osada H, Isono K, Yoshihama M. New types of liposidomycins which inhibit bacterial peptidoglycan synthesis produced by Streptomyces. Actinomycetol., 12, 110-119 (1998)
Osada H. Bioprobes for investigating mammalian cell cycle control. J. Antibiot., 51, 973-981 (1998)
Kakeya H, Osada H. Induction of neurite outgrowth by epolactaene derivatives, 3-substituted 3-pyrrolin-2-ones. RIKEN Review , 18, 35-36 (1998)
Osada H. Discovery and mechanism of action of nonpeptide neuritogenic compounds. Drugs of the Future , 23, 395-399 (1998)
Osada H. Inhibitors of eukaryotic cell cycle from microbial metabolites. Biotechnology (Moscow) , 7-8, 205-209 (1995)
Osada H. Fascinating bioactive compounds from actinomycetes. Actinomycetol., 9, 254-262 (1995)
Lami N, Osada H. Screening of biologically active secondary metabolites from Zairian (Africa) microorganisms. RIKEN Review, 3, 15-16 (1993)
Osada H, Hanaoka F, Isono K. Inhibitors of eukaryotic cell cycle from microbial metabolites. J. Cell. Biochem. suppl., 17A, 296 (1993)
Osada H, Isono K. Microbial secondary metabolites which regulate mammalian cell growth. In: C. Nash (ed.), Developments in Industrial Microbiology Series, Vol. 32, pp. 237-245. Dubuque: Wm. C. Brown Publishers (1993).
Osada H, Hanaoka F, Isono K. Effects of microbial inhibitors of protein kinases and phosphatases on the cell cycle progression of mouse tsFT210 cells. Second joint meeting of the AACR/JCA (Molecular oncology as a basis for new strategies in cancer therapy), Honolulu (1992)
Osada H, Isono K. Microbial secondary metabolites regulating mam malian cell growth. 2nd International conference on the biotechnology of microbial products. (1990)
Ubukata M, X.C. Cheng, Osada H, Magae J, Yamasaki M, Isono K. Tautomycin, a new antibiotic which regulates eukaryotic cell growth. 29th Interscience conference on antimicrobial agents and chemotherapy. (1989)
Osada H, Sonoda T, Isono K. Epiderstatin, a new antibiotic, which inhibits the mitogenic activity induced by epidermal growth factor. 29th Interscience conference on antimicrobial agents and chemotherapy. (1989)
Osada H, Magae J, Tsunoda K, Watanabe C, Isono K. Rapid screening method for activators/inhibitors of protein kinase C. Trends in Actinomycetology in Japan, Actinomycetologica Forum, 33-35 (1989)
Ubukata M, Osada H, Isono K. Synthesis and biological activity of nucleoside antibiotics, ascamycin and amino acid analogs. Nucleic Acids Res. Symp. Ser., 16, 81-83 (1985)
Isono K, Uramoto M, Osada H, Ubukata M, Kusakabe H, Koyama T, Miyata N, Sethi SK, McCloskey JA. Structure and biological activity of ascamycin, a new nucleoside antibiotic. Nucleic Acids Res. Symp. Ser., 15, 65- 67 (1984)
[ doi: 10.1093/jimb/kuab058 ]