ケミカルバイオロジー研究グループ（終了）
Linearolide A and B
- Structure
-
A:
B:
- Producing organism
- Streptomyces sp. RK95-74
- Biological activity
- weak cytotoxicity
- Abstract
- Although all Streptomyces strains are now thought to have 20-30 gene clusters for secondary metabolite biosynthesis, we cannot actually identify so many kinds of metabolites from one strain by conventional methods. Using Streptomyces sp. RK95-74, previously found as a cytotrienin producer, we searched new metabolites other than cytotrienin derivatives. Following the cultivation with new media and the peak-guided fractionation, we have found new compounds with new polyketide scaffold, named linearolides A and B.
- References
- Ueki M, Koshiro N, Aono H, Kawatani M, Uramoto M, Kawasaki H, Osada H.: Isolation of new polyketide metabolites, linearolides A and B, from Streptomyces sp. RK95-74.
J Antibiot, 66(6): 333-337 (2013)
[ doi: 10.1038/ja.2013.19 ]- Ueki M, Koshiro N, Aono H, Kawatani M, Uramoto M, Kawasaki H, Osada H.: Isolation of new polyketide metabolites, linearolides A and B, from Streptomyces sp. RK95-74.