ケミカルバイオロジー研究グループ（終了）
Hitoyol A, B
- Structure
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A:
B:
A B - Producing organism
- Coprinopsis cinerea (NBRC 100011)
- Biological activity
- hitoyol A, no activities
hitoyol B, weak anti-malarial activity - Abstract
- Hitoyol A and B, isolated from the culture broth of Basidiomycete Coprinopsis cinerea (NBRC 100011), are novel skeletal norsesquiterpenoids. Their structures and absolute configurations were determined by the extensive spectroscopic analyses including X-ray and ECD. Hitoyol A was possibly biosynthesized from a known sesquiterpenoid lagopodin B via a decarboxylation-induced cyclization. Hitoyol B showed weak anti-malarial activity (IC50 = 59 μM).
- References
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Isolation, identification, and biological activities
- Otaka J, Hashizume D, Masumoto Y, Muranaka A, Uchiyama M, Koshino H, Futamura Y, Osada H.: Hitoyol A and B, Two Norsesquiterpenoids from the Basidiomycete Coprinopsis cinerea.
Org Lett, 19(15), 4030–4033 (2017)
[ doi: 10.1021/acs.orglett.7b01784 ] - Otaka J, Hashizume D, Masumoto Y, Muranaka A, Uchiyama M, Koshino H, Futamura Y, Osada H.: Hitoyol A and B, Two Norsesquiterpenoids from the Basidiomycete Coprinopsis cinerea.