ケミカルバイオロジー研究グループ(終了)

Liposidomycin B, C

Structure
B: NPEdia
C: NPEdia
Liposidomycin
Producing organism
Streptomyces griseosporeus
Biological activity
antibacterial activity, inhibition of peptide glycan synthesis
Abstract
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References
isolation
  • Isono K, Uramoto M, Kusakabe H, Kimura K, Isaki K, Nelson CC, McCloskey JA.: Liposidomycins: novel nucleoside antibiotics which inhibit bacterial peptidoglycan synthesis.
    J Antibiot, 38(11): 1617-1621 (1985) PMID: 4077739
  • biological activity
  • Muroi M, Kimura K, Osada H, Inukai M, Takatsuki A.: Liposidomycin B inhibits in vitro formation of polyprenyl (pyro)phosphate N-acetylglucosamine, an intermediate in glycoconjugate biosynthesis.
    J Antibiot, 50(1): 103-104 (1997) PMID: 9066776
  • Kimura K, Ikeda Y, Kagami S, Yoshihama M, Suzuki K, Osada H, Isono K.: Selective inhibition of the bacterial peptidoglycan biosynthesis by the new types of liposidomycins.
    J Antibiot, 51(12): 1099-1104 (1998) PMID: 10048569
  • related compounds
  • Kimura K, Kagami S, Ikeda Y, Takahashi H, Yoshihama M, Kusakabe H, Osada H, Isono K.: New types of liposidomycins that inhibit bacterial peptidoglycan synthesis and are produced by Streptomyces. I. Producing organism and medium components.
    J Antibiot, 51(7): 640-646 (1998) PMID: 9727390
  • Kimura K, Ikeda Y, Kagami S, Yoshihama M, Ubukata M, Esumi Y, Osada H, Isono K.: New types of liposidomycins that inhibit bacterial peptidoglycan synthesis and are produced by Streptomyces. II. Isolation and structure elucidation.
    J Antibiot, 51(7): 647-654 (1998) PMID: 9727391
  • Additional information