ケミカルバイオロジー研究グループ（終了）
Neopeptin A, B, C
- Structure
-
A:
B:
C:
- Producing organism
- Streptomyces sp.
- Biological activity
- fungal cell wall synthesis inhibition
- Abstract
- The antifungal antibiotics, neopeptin A, B, C, were found to be cyclic lipopeptides containingunusual amino acids, their structures being elucidated on the basis of chemical and spectroscopic evidence. They inhibited mannoprotein and β-1,3-gllucan synthestases from Saccharomyces cerevisiae. The structure-biological activity relationship is discussed.
- References
-
isolation and structural determination
- Ubukata M, Uramoto M, Uzawa J, Isono K.
Structure and biological activity of neopeptins A, B, and C, inhibitors of fungal cell wall glycan synthesis.
Agric. Biol. Chem. 50, 357-365 (1986) [ doi: 10.1271/bbb1961.50.357 ]- Ubukata M.
Chemical studies on new antibiotics.
Nippon Nogei Kagaku Kaishi 62(11), 1629-1636 (1988) [ doi: 10.1271/nogeikagaku1924.62.1629 ] - Ubukata M, Uramoto M, Uzawa J, Isono K.