Chemical synthesis of bioactive compounds
Many bioactive compounds have been found by the screening of compounds from microbial source and RIKEN NPDepo in the chemical biology research group. They are expected to be utilized for medicinal drugs, agrochemicals, and also bioprobes as biochemical tools for investigating cell function. Derivatives of these compounds have been chemically synthesized for the identification of the target protein, structure-activity relationship study, and optimization of the active structure. Structure determination and synthesis of compounds for the elucidation of biosynthetic pathway are also carried out.