Yano A, Tsutsumi S, Soga S, Lee MJ, Trepel J, Osada H, Neckers L.: Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone. Proc Natl Acad Sci U S A, 105(40): 15541-15546 (2008) [ doi: 10.1073/pnas.0805354105 ]
Miyazaki I, Simizu S, Ichimiya H, Kawatani M, Osada H.: Robust and systematic drug screening method using chemical arrays and the protein library: identification of novel inhibitors of carbonic anhydrase II. Biosci Biotechnol Biochem, 72(10): 2739-2749 (2008) [ doi: 10.1271/bbb.80383 ]
Hiraoka K, Zenmyo M, Watari K, Iguchi H, Fotovati A, Kimura YN, Hosoi F, Shoda T, Nagata K, Osada H, Ono M, Kuwano M.: Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/macrophages. Cancer Sci, 99(8): 1595-1602 (2008) [ doi: 10.1111/j.1349-7006.2008.00880.x ]
Li W, Ju J, Rajski SR, Osada H, Shen B.: Characterization of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus unveiling new insights into dialkylmaleic anhydride and polyketide biosynthesis. J Biol Chem, 283(42): 28607-28617 (2008) [ doi: 10.1074/jbc.M804279200 ]
Kawatani M, Okumura H, Honda K, Kanoh N, Muroi M, Dohmae N, Takami M, Kitagawa M, Futamura Y, Imoto M, Osada H.: The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I. Proc Natl Acad Sci U S A, 105(33): 11691-11696 (2008) [ doi: 10.1073/pnas.0712239105 ]
Lai NS, Simizu S, Morisaki D, Muroi M, Osada H.: Requirement of the conserved, hydrophobic C-terminus region for the activation of heparanase. Exp Cell Res, 314(15): 2834-2845 (2008) [ doi: 10.1016/j.yexcr.2008.07.004 ]
Hayashi Y, Shoji M, Ishikawa H, Yamaguchi J, Tamura T, Imai H, Nishigaya Y, Takabe K, Kakeya H, Osada H.: The asymmetric total synthesis of (+)-cytotrienin a, an ansamycin-type anticancer drug. Angew Chem Int Ed Engl, 47(35): 6657-6660 (2008) [ doi: 10.1002/anie.200802079 ]
Saito A, Kawai K, Takayama H, Sudo T, Osada H.: Improvement of photoaffinity SPR imaging platform and determination of the binding site of p62/SQSTM1 to p38 MAP kinase. Chem Asian J, 3(8-9): 1607-1612 (2008) [ doi: 10.1002/asia.200800099 ]
Asami Y, Kakeya H, Komi Y, Kojima S, Nishikawa K, Beebe K, Neckers L, Osada H.: Azaspirene, a fungal product, inhibits angiogenesis by blocking Raf-1 activation. Cancer Sci, 99(9): 1853-1858 (2008) [ doi: 10.1111/j.1349-7006.2008.00890.x ]
Kamiyama H, Usui T, Sakurai H, Shoji M, Hayashi Y, Kakeya H, Osada H.: Epoxyquinol B, a naturally occurring pentaketide dimer, inhibits NF-kappaB signaling by crosslinking TAK1. Biosci Biotechnol Biochem, 72(7): 1894-1900 (2008) [ doi: 10.1271/bbb.80142 ]
Shimizu T, Usui T, Fujikura M, Kawatani M, Satoh T, Machida K, Kanoh N, Woo JT, Osada H, Sodeoka M.: Synthesis and biological activities of reveromycin A and spirofungin A derivatives. Bioorg Med Chem Lett, 18(13): 3756-3760 (2008) [ doi: 10.1016/j.bmcl.2008.05.054 ]
Jain HD, Zhang C, Zhou S, Zhou H, Ma J, Liu X, Liao X, Deveau AM, Dieckhaus CM, Johnson MA, Smith KS, Macdonald TL, Kakeya H, Osada H, Cook JM.: Synthesis and structure-activity relationship studies on tryprostatin A, an inhibitor of breast cancer resistance protein. Bioorg Med Chem, 16(8): 4626-4651 (2008) [ doi: 10.1016/j.bmc.2008.02.050 ]
Kamiyama H, Usui T, Uramoto M, Takagi H, Shoji M, Hayashi Y, Kakeya H, Osada H.: Fungal metabolite, epoxyquinol B, crosslinks proteins by epoxy-thiol conjugation. J Antibiot, 61(2): 94-97 (2008) [ doi: 10.1038/ja.2008.117 ]
Kawai K, Saito A, Sudo T, Osada H.: Specific regulation of cytokine-dependent p38 MAP kinase activation by p62/SQSTM1. J Biochem, 143(6): 765-772 (2008) [ doi: 10.1093/jb/mvn027 ]
Kamiyama H, Kakeya H, Usui T, Nishikawa K, Shoji M, Hayashi Y, Osada H.: Epoxyquinol B shows antiangiogenic and antitumor effects by inhibiting VEGFR2, EGFR, FGFR, and PDGFR. Oncol Res, 17(1): 11-21 (2008) [ doi: 10.3727/096504008784046063 ]
Sato Y, Kamiyama H, Usui T, Saito T, Osada H, Kuwahara S, Kiyota H.: Synthesis and anti-angiogenic activity of cortistatin analogs. Biosci Biotechnol Biochem, 72(11): 2992-2997 (2008) [ doi: 10.1271/bbb.80562 ]
[ doi: 10.1073/pnas.0805354105 ]