Uchimura S, Oguchi Y, Katsuki M, Usui T, Osada H, Nikawa J, Ishiwata S, Muto E.: Identification of a strong binding site for kinesin on the microtubule using mutant analysis of tubulin. EMBO J, 25(24): 5932-5941 (2006) [ doi: 10.1038/sj.emboj.7601442 ]
Ueki M, Galonić DP, Vaillancourt FH, Garneau-Tsodikova S, Yeh E, Vosburg DA, Schroeder FC, Osada H, Walsh CT.: Enzymatic generation of the antimetabolite gamma,gamma-dichloroaminobutyrate by NRPS and mononuclear iron halogenase action in a streptomycete. Chem Biol, 13(11): 1183-1191 (2006) [ doi: 10.1016/j.chembiol.2006.09.012 ]
Usui T, Nagumo Y, Watanabe A, Kubota T, Komatsu K, Kobayashi J, Osada H.: Brasilicardin A, a natural immunosuppressant, targets amino Acid transport system L. Chem Biol, 13(11): 1153-1160 (2006) [ doi: 10.1016/j.chembiol.2006.09.006 ]
Taguchi H, Ohkubo A, Sekine M, Seio K, Kakeya H, Osada H, Sasaki T.: Synthesis and biological properties of new phosmidosine analogs having an N-acylsulfamate linkage. Nucleosides Nucleotides Nucleic Acids, 25(4-6): 647-654 (2006) [ doi: 10.1080/15257770600686360 ]
Tomiki, T., Saito, T., Ueki, M., Konno, H., Asaoka, T., Suzuki, R., Uramoto, M., Kakeya, H., and Osada, H. RIKEN natural products encyclopedia.(RIKEN NPEdia), a chemical database of RIKEN natural products depository (RIKEN NPDepo). J. Comp. Aid. Chem., 7, 157-162 (2006) [ doi: 10.2751/jcac.7.157 ]
Kobayashi Y, Mizunuma M, Osada H, Miyakawa T.: Identification of Saccharomyces cerevisiae ribosomal protein L3 as a target of curvularol, a G1-specific inhibitor of mammalian cells. Biosci Biotechnol Biochem, 70(10): 2451-2459 (2006) [ doi: 10.1271/bbb.60186 ]
Kanoh N, Asami A, Kawatani M, Honda K, Kumashiro S, Takayama H, Simizu S, Amemiya T, Kondoh Y, Hatakeyama S, Tsuganezawa K, Utata R, Tanaka A, Yokoyama S, Tashiro H, Osada H.: Photo-cross-linked small-molecule microarrays as chemical genomic tools for dissecting protein-ligand interactions. Chem Asian J, 1(6): 789-797 (2006) [ doi: 10.1002/asia.200600208 ]
Matsuzawa M, Kakeya H, Yamaguchi J, Shoji M, Onose R, Osada H, Hayashi Y.: Enantio- and diastereoselective total synthesis of (+)-panepophenanthrin, a ubiquitin-activating enzyme inhibitor, and biological properties of its new derivatives. Chem Asian J, 1(6): 845-851 (2006) [ doi: 10.1002/asia.200600199 ]
Okumura H, Nakazawa J, Tsuganezawa K, Usui T, Osada H, Matsumoto T, Tanaka A, Yokoyama S.: Phenothiazine and carbazole-related compounds inhibit mitotic kinesin Eg5 and trigger apoptosis in transformed culture cells. Toxicol Lett, 166(1): 44-52 (2006) [ doi: 10.1016/j.toxlet.2006.05.011 ]
Asami Y, Kakeya H, Okada G, Toi M, Osada H.: RK-95113, a new angiogenesis inhibitor produced by Aspergillus fumigatus. J Antibiot, 59(11): 724-728 (2006) [ doi: 10.1038/ja.2006.97 ]
Hakamata W, Muroi M, Nishio T, Oku T, Takatsuki A, Osada H, Fukuhara K, Okuda H, Kurihara, M.: N-linked oligosaccharide processing enzymes as molecular targets for drug discovery. J Appl Glycosci., 53, 149-154 (2006) [ doi: 10.5458/jag.53.149 ]
Watanabe N, Nishihara Y, Yamaguchi T, Koito A, Miyoshi H, Kakeya H, Osada H.: Fumagillin suppresses HIV-1 infection of macrophages through the inhibition of Vpr activity. FEBS Lett, 580(11): 2598-2602 (2006) [ doi: 10.1016/j.febslet.2006.04.007 ]
Li W, Ju J, Osada H, Shen B.: Utilization of the methoxymalonyl-acyl carrier protein biosynthesis locus for cloning of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus. J Bacteriol, 188(11): 4148-4152 (2006) [ doi: 10.1128/JB.00172-06 ]
Kazami S, Muroi M, Kawatani M, Kubota T, Usui T, Kobayashi J, Osada H.: Iejimalides show anti-osteoclast activity via V-ATPase inhibition. Biosci Biotechnol Biochem, 70(6): 1364-1370 (2006) [ doi: 10.1271/bbb.50644 ]
Kanoh N, Kyo M, Inamori K, Ando A, Asami A, Nakao A, Osada H.: SPR imaging of photo-cross-linked small-molecule arrays on gold. Anal Chem, 78(7): 2226-2230 (2006) [ doi: 10.1021/ac051777j ]
Machida K, Ohta Y, Osada H.: Suppression of apoptosis by cyclophilin D via stabilization of hexokinase II mitochondrial binding in cancer cells. J Biol Chem, 281(20): 14314-14320 (2006) [ doi: 10.1074/jbc.M513297200 ]
Woo JT, Kawatani M, Kato M, Shinki T, Yonezawa T, Kanoh N, Nakagawa H, Takami M, Lee KH, Stern PH, Nagai K, Osada H.: Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Proc Natl Acad Sci U S A, 103(12): 4729-4734 (2006) [ doi: 10.1073/pnas.0505663103 ]
Temkin V, Huang Q, Liu H, Osada H, Pope RM.: Inhibition of ADP/ATP exchange in receptor-interacting protein-mediated necrosis. Mol Cell Biol, 26(6): 2215-2225 (2006) [ doi: 10.1128/MCB.26.6.2215-2225.2006 ]
Yamaguchi J, Toyoshima M, Shoji M, Kakeya H, Osada H, Hayashi Y.: Concise enantio- and diastereoselective total syntheses of fumagillol, RK-805, FR65814, ovalicin, and 5-demethylovalicin. Angew Chem Int Ed Engl, 45(5): 789-793 (2006) [ doi: 10.1002/anie.200502826 ]
Shiina I, Uchimaru T, Shoji M, Kakeya H, Osada H, Hayashi Y.: Computational study on the reaction mechanism of the key thermal [4 + 4] cycloaddition reaction in the biosynthesis of epoxytwinol A. Org Lett, 8(6): 1041-1044 (2006) [ doi: 10.1021/ol052916m ]
[ doi: 10.1038/sj.emboj.7601442 ]