Zearalenone and zearalenone cleavage product
- Structure
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Zearalenone:
Zearalenone cleavage product:
- Producing organism
- Fusarium (zearalenone),
Clonostachys roseal IFO 7063 (cleavage product) - Biological activity
- estrogenic activity (zearalenone),
detoxified compound (cleavage product) - Abstract
- Zearalenones are mycotoxins with estrogenic activity consisting of a resorcinol moiety fused to a 14-membered macrocyclic lactone and are produced by various Fusarium species. We found that Clonostachys rosea IFO 7063 was effectively capable of converting zearalenone to cleavage product, 1-(3,5-dihydroxyphenyl)-10′-hydroxy-1′E-undecene-6′-one. Moreover, the cleavage product did not show potent estrogenic activity like that of Zearalenone and 17β-estradiol in the human breast cancer MCF-7 cell proliferation assay.
- References
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- Takahashi-Ando N, Kimura M, Kakeya H, Osada H, Yamaguchi I.: A novel lactonohydrolase responsible for the detoxification of zearalenone: enzyme purification and gene cloning.
Biochem J, 365(Pt 1), 1-6 (2002)
[ doi: 10.1042/BJ20020450 ]
- Kakeya H, Takahashi-Ando N, Kimura M, Onose R, Yamaguchi I, Osada H.: Biotransformation of the mycotoxin, zearalenone, to a non-estrogenic compound by a fungal strain of Clonostachys sp.
Biosci Biotechnol Biochem, 66(12), 2723-2726 (2002) [ doi: 10.1271/bbb.66.2723 ]
- Takahashi-Ando N, Kimura M, Kakeya H, Osada H, Yamaguchi I.: A novel lactonohydrolase responsible for the detoxification of zearalenone: enzyme purification and gene cloning.