Curvularol
- Structure
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- Producing organism
- Curvularia sp. RK97-F166 (isolated in Nagasaki, Japan)
- Biological activity
- eucaryotic protein synthesis inhitibion
- Abstract
- A new cell growth inhibitor, curvularol, was isolated from the fermentation broth of Curvularia sp. RK97-F166. Curvularol showed no antibacterial activity, and very weak antifungal activity. However, curvularol inhibited the cell cycle progression of normal rat kidney (NRK) cells in G1 phase at 150 ng/ml. Curvularol induced the morphological reversion of srcts-transformed NRK cells at 100 ng/ml, and inhibited protein synthesis same as cycloheximide.
- References
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isolation and structural determination
- Honda Y, Ueki M, Okada G, Onose R, Usami R, Horikoshi K, Osada H.: Isolation, and biological properties of a new cell cycle inhibitor, curvularol, isolated from Curvularia sp. RK97-F166.
J Antibiot, 54(1): 10-16 (2001)
- Honda Y, Ueki M, Okada G, Onose R, Usami R, Horikoshi K, Osada H.: Isolation, and biological properties of a new cell cycle inhibitor, curvularol, isolated from Curvularia sp. RK97-F166.