理化学研究所 環境資源科学研究センター
ケミカルバイオロジー グループ(Archives)

グループディレクター 長田裕之

• 印刷

長田　裕之
（おさだ ひろゆき)
D.Agr.

研究の興味

なぜ、微生物が、化学的にも生物学的にも多種多様な化合物を作るのか不思議に思います。その謎を解くために、微生物の生合成遺伝子を研究しています。また、生命機能解析の探索針(バイオプローブ）を用いたケミカルバイオロジー研究と、癌の分子標的治療を目指した研究で社会貢献したいと思います。

趣味

飲酒談笑, サイクリング

兼務

• 理研-マックスプランク連携研究部門 部門長
• 静岡大学大学院 客員教授（グリーン科学技術研究所）
• 韓国生命工学研究所（KRIBB）招聘研究員
• 加藤記念バイオサイエンス振興財団　理事
• バイオインダストリー協会　評議員
• 野田産業科学研究所　評議員
• 微生物化学研究会　評議員
• 日本感染症医薬品協会 常務理事

学会等

• 日本ケミカルバイオロジー学会 会長
• 日本がん分子標的治療学会 理事
• 日本農芸化学会 フェロー
• 日本癌学会 名誉会員
• 日本放線菌学会 名誉会員
• 日本微生物学連盟 常務理事
• 日本生化学会 理事

編集委員

• Assay and Drug Development Technology
• Cancer Science
• Journal of Antibiotics
• Journal of General and Applied Microbiology
• Journal of Microbiology and Biotechnology
• Oncology Research

編集アドバイザー

• ACS Chemical Biology

主な原著論文

1. Nagasawa I, Muroi M, Kawatani M, Ohishi T, Ohba SI, Kawada M & Osada H.: Identification of a small compound targeting PKM2-regulated signaling using 2D gel electrophoresis-based proteome-wide CETSA. Cell Chem Biol, 27(2), 186-196.e4 (2020) [ doi: 10.1016/j.chembiol.2019.11.010 ]
2. Simpkins SW, Deshpande R, Nelson J, Li SC, Piotrowski JS, Ward HN, Yashiroda Y, Osada H, Yoshida M, Boone C & Myers CL.: Using BEAN-counter to quantify genetic interactions from multiplexed barcode sequencing experiments. Nat Protoc, 14(2): 415-440 (2019) [ doi: 10.1038/s41596-018-0099-1 ]
3. Piotrowski JS, Li SC, Deshpande R, Simpkins SW, Nelson J, Yashiroda Y, Barber JM, Safizadeh H, Wilson E, Okada H, Gebre AA, Kubo K, Torres NP, LeBlanc MA, Andrusiak K, Okamoto R, Yoshimura M, DeRango-Adem E, van Leeuwen J, Shirahige K, Baryshnikova A, Brown GW, Hirano H, Costanzo M, Andrews B, Ohya Y, Osada H, Yoshida M, Myers CL & Boone C.: Functional annotation of chemical libraries across diverse biological processes. Nat Chem Biol, 13(9): 982-993 (2017) [ doi: 10.1038/nchembio.2436 ]
4. Ursu A, Illich DJ, Takemoto Y, Porfetye AT, Zhang M, Brockmeyer A, Janning P, Watanabe N, Osada H, Vetter IR, Ziegler S, Schöler HR & Waldmann H.: Epiblastin A induces reprogramming of epiblast stem cells into embryonic stem cells by inhibition of casein kinase 1. Cell Chem Biol, 23(4): 494-507 (2016) [ doi: 10.1016/j.chembiol.2016.02.015 ]
5. Ray L, Valentic TR, Miyazawa T, Withall DM, Song L, Milligan JC, Osada H, Takahashi S, Tsai SC & Challis GL.: A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units. Nat Commun, 7: 13609 (2016) [ doi: 10.1038/ncomms13609 ]
6. Hasebe F, Matsuda K, Shiraishi T, Futamura Y, Nakano T, Tomita T, Ishigami K, Taka H, Mineki R, Fujimura T, Osada H, Kuzuyama T & Nishiyama T.: Amino group carrier protein-mediated secondary metabolite biosynthesis in Streptomyces Nat Chem Biol, 12: 967–972 (2016) [ doi: 10.1038/nchembio.2181 ]
7. Yun CS, Motoyama T & Osada H.: Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS-PKS hybrid enzyme. Nat Commun, 6: 8758 (2015) [ doi: 10.1038/ncomms9758 ]
8. Soeda Y, Yoshikawa M, Almeida OF, Sumioka A, Maeda S, Osada H, Kondoh Y, Saito A, Miyasaka T, Kimura T, Suzuki M, Koyama H, Yoshiike Y, Sugimoto H, Ihara Y & Takashima A.: Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups. Nat Commun, 6: 10216 (2015) [ doi: 10.1038/ncomms10216 ]
9. Takahashi S, Toyoda A, Sekiyama Y, Takagi H, Nogawa T, Uramoto M, Suzuki R, Koshino H, Kumano T, Panthee S, Dairi T, Ishikawa J, Ikeda H, Sakaki Y & Osada H.: Reveromycin A biosynthesis uses RevG and RevJ for stereospecific spiroacetal formation. Nat Chem Biol. 7: 461-468 (2011) [ doi: 10.1038/nchembio.583 ]
10. Sun Y, Hahn F, Demydchuk Y, Chettle J, Tosin M, Osada H & Leadlay PF : In vitro reconstruction of tetronate RK-682 biosynthesis. Nature Chem Biol, 6, 99-101 (2010) [ doi: 10.1038/nchembio.285 ]
11. Miyazaki I, Simizu S, Okumura H, Takagi S & Osada H: A small-molecule inhibitor shows that pirin regulates migration of melanoma cells. Nature Chem Biol., 6,667-673,(2010) [ doi: 10.1038/nchembio.423 ]
12. Yano A, Tsutsumi S, Soga S, Lee MJ, Trepel J, Osada H & Neckers L.: Inhibition of Hsp90 activates osteoclast c-Src signaling and promotes growth of prostate carcinoma cells in bone. Proc Natl Acad Sci U S A, 105(40): 15541-15546 (2008) [ doi: 10.1073/pnas.0805354105 ]
13. Kawatani M, Okumura H, Honda K, Kanoh N, Muroi M, Dohmae N, Takami M, Kitagawa M, Futamura Y, Imoto M & Osada H.: The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I. Proc Natl Acad Sci U S A, 105(33): 11691-11696 (2008) [ doi: 10.1073/pnas.0712239105 ]
14. Woo JT, Kawatani M, Kato M, Shinki T, Yonezawa T, Kanoh N, Nakagawa H, Takami M, Lee KH, Stern PH, Nagai K & Osada H.: Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Proc Natl Acad Sci U S A, 103(12): 4729-4734 (2006) [ doi: 10.1073/pnas.0505663103 ]
15. Watanabe N, Arai H, Nishihara Y, Taniguchi M, Watanabe N, Hunter T & Osada H.: M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP. Proc Natl Acad Sci U S A, 101(13): 4419-4424 (2004) [ doi: 10.1073/pnas.0307700101 ]
16. Watanabe N, Arai H, Iwasaki J, Shiina M, Ogata K, Hunter T & Osada H.: Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways. Proc Natl Acad Sci U S A, 102(33): 11663-11668 (2005) [ doi: 10.1073/pnas.0500410102 ]
17. Simizu S & Osada H.: Mutations in the Plk gene lead to instability of Plk protein in human tumour cell lines. Nat Cell Biol, 2(11): 852-854 (2000) [ doi: 10.1038/35041102 ]

主な総説

1. Muroi M & Osada H: Proteomic profiling for target identification of biologically active small molecules using 2D DIGE. Methods Mol Biol, 1888, 127-139 (2019) [ doi: 10.1007/978-1-4939-8891-4_7 ]
2. Osada H.: Trends in Bioprobe Research.Bioprobes (Ed. H. Osada), Springer, 1-10 (2017) [ doi: 10.1007/978-4-431-56529-1_1 ]
3. Watanabe N & Osada H.: Small molecules that target phosphorylation dependent protein-protein interaction. Bioorg Med Chem, 24(15): 3246-3254 (2016) [ doi: 10.1016/j.bmc.2016.03.023 ]
4. Osada H.: Chemical and biological studies of reveromycin A. J Antibiot, 69(10): 723-730 (2016) [ doi: 10.1038/ja.2016.57 ]
5. Muroi M, Futamura Y, & Osada H.: Integrated profiling methods for identifying the targets of bioactive compounds: MorphoBase and ChemProteoBase. Nat Prod Rep, 33(5): 621-625 (2016) [ doi: 10.1039/c5np00106d ]