Biosynthetic Gene Cluster of Microbial Products in RIKEN (Chemical Biology Research Group and Natural Product Biosynthesis Unit)

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	Compound name and structure	Gene cluster	References
A	1233A		Kato S, Motoyama T, Uramoto M, Nogawa T, Kamakura T, Osada H. J Antibiot, 73(7): 475-479 (2020) [ doi: 10.1038/s41429-020-0295-4 ]
	Alkyldihydropyrones	a type III polyketide synthase	Aizawa T, Kim SY, Takahashi S, Koshita M, Tani M, Futamura Y, Osada H, Funa N. J Antibiot, 67(12): 819-823 (2014) [ doi: 10.1038/ja.2014.80 ]
	Astellolide		Shinohara Y, Takahashi S, Osada H, Koyama Y. Sci Rep, 6: 32865 (2016) [ doi: 10.1038/srep32865 ]
C	Cyclopiazonic acid		Kato N, Tokuoka M, Shinohara Y, Kawatani M, Uramoto M, Seshime Y, Fujii I, Kitamoto K, Takahashi T, Takahashi S, Koyama Y, Osada H. Chembiochem, 12(9): 1376-1382 (2011) [ doi: 10.1002/cbic.201000672 ]
D	6-Dimethylallylindole-3-carbaldehyde		Takahashi S, Takagi H, Toyoda A, Uramoto M, Nogawa T, Ueki M, Sakaki Y, Osada H. J Bacteriol, 192(11): 2839-2851 (2010) [ doi: 10.1128/JB.01557-09 ]
F	Fumitremorgin		Kato N, Suzuki H, Okumura H, Takahashi S, Osada H. Biosci Biotechnol Biochem, 77(5): 1061-1067 (2013) [ doi: 10.1271/bbb.130026 ] Kato N, Suzuki H, Takagi H, Uramoto M, Takahashi S, Osada H. Chembiochem, 12(5): 711-714 (2011) [ doi: 10.1002/cbic.201000562 ] Kato N, Suzuki H, Takagi H, Asami Y, Kakeya H, Uramoto M, Usui T, Takahashi S, Sugimoto Y, Osada H. Chembiochem, 10(5): 920-928 (2009) 　[ doi: 10.1002/cbic.200800787 ]
K	Kinanthraquinone		Takao R, Sakai K, Koshino H, Osada H, Takahashi S. Biosci Biotechnol Biochem, 85(3): 714-721 (2021) [ doi: 10.1093/bbb/zbaa082 ] Sakai K, Takao R, Koshino H, Futamura Y, Osada H, Takahashi S. J Antibiot, 74(9): 593-595 (2021) [ doi: 10.1038/s41429-021-00442-1 ]
L	Lucilactaene		Kato S, Motoyama T, Futamura Y, Uramoto M, Nogawa T, Hayashi T, Hirota H, Tanaka A, Takahashi-Ando N, Kamakura T, Osada H. Biosci Biotechnol Biochem, 84(6): 1303-1307 (2020) [ doi: 10.1080/09168451.2020.1725419 ]
N	Nectriapyrone		Motoyama T, Nogawa T, Hayashi T, Hirota H, Osada H. Chembiochem, 20(5): 693-700 (2019) [ doi: 10.1002/cbic.201800620 ]
P	Phoslactomycin		Palaniappan N, Kim BS, Sekiyama Y, Osada H, Reynolds KA. J Biol Chem, 278(37): 35552-35557 (2003) [ doi: 10.1074/jbc.M305082200 ] Sekiyama Y, Palaniappan N, Reynolds KA, Osada H. Tetrahedron, 59: 7465-7471 (2003) [ doi: 10.1016/S0040-4020(03)01205-5 ]
	Pyriculol		Furuyama Y, Motoyama T, Nogawa T, Hayashi T, Hirota H, Kiyota H, Kamakura T, Osada H. Biosci Biotechnol Biochem, 85(1): 126-133 (2021) [ doi: 10.1093/bbb/zbaa035 ] Furuyama Y, Motoyama T, Nogawa T, Kamakura T, Osada H. Biosci Biotechnol Biochem, 85(5): 1290-1293 (2021) [ doi: 10.1093/bbb/zbab021 ]
R	Reveromycin whole info zoom in revI     zoom in revR, S, T		--- whole info --- Takahashi S, Toyoda A, Sekiyama Y, Takagi H, Nogawa T, Uramoto M, Suzuki R, Koshino H, Kumano T, Panthee S, Dairi T, Ishikawa J, Ikeda H, Sakaki Y, Osada H. Nat Chem Biol, 7(7): 461-468 (2011) [ doi: 10.1038/nchembio.583 ] --- zoom in revI --- Nogawa T, Takahashi S, Sekiyama Y, Takagi H, Uramoto M, Koshino H, Kawatani M, Shimizu T, Osada H. J Antibiot, 66(4): 247-250 (2013) [ doi: 10.1038/ja.2012.115 ] Takahashi S, Nagano S, Nogawa T, Kanoh N, Uramoto M, Kawatani M, Shimizu T, Miyazawa T, Shiro Y, Osada H. J Biol Chem, 289(47): 32446-32458 (2014) [ doi: 10.1074/jbc.M114.598391 ] --- zoom in revR, S, T --- Miyazawa T, Takahashi S, Kawata A, Panthee S, Hayashi T, Shimizu T, Nogawa T, Osada H. J Biol Chem, 290(45): 26994-27011 (2015) [ doi: 10.1074/jbc.M115.677195 ]
	RK-682		Sun Y, Hahn F, Demydchuk Y, Chettle J, Tosin M, Osada H, Leadlay PF. Nat Chem Biol, 6(2): 99-101 (2010) [ doi: 10.1038/nchembio.285 ]
S	Stambomycin		Ray L, Valentic TR, Miyazawa T, Withall DM, Song L, Milligan JC, Osada H, Takahashi S, Tsai SC, Challis GL. Nat Commun, 7: 13609 (2016) [ doi: 10.1038/ncomms13609 ]
T	Tautomycetin		Li W, Luo Y, Ju J, Rajski SR, Osada H, Shen B. J Nat Prod, 72(3): 450-459 (2009) [ doi: 10.1021/np8007478 ]
	Telomestatin		Amagai K, Ikeda H, Hashimoto J, Kozone I, Izumikawa M, Kudo F, Eguchi T, Nakamura T, Osada H, Takahashi S, Shin-Ya K. Sci Rep, 7(1): 3382 (2017) [ doi: 10.1038/s41598-017-03308-5 ]
	Tenuazonic acid		Yun CS, Motoyama T, Osada H. Nat Commun, 6: 8758 (2015) [ doi: 10.1038/ncomms9758 ] Motoyama T, Osada H. Bioorg Med Chem Lett, 26(24): 5843-5850 (2016) [ doi: 10.1016/j.bmcl.2016.11.013 ] Yun CS, Motoyama T, Osada H.: Regulatory Mechanism of Mycotoxin Tenuazonic Acid Production in Pyricularia oryzae. ACS Chem Biol, 12(9): 2270-2274 (2017) [ doi: 10.1021/acschembio.7b00353 ]
	Terpendole E		Motoyama T, Hayashi T, Hirota H, Ueki M, Osada H. Chem Biol, 19(12): 1611-1619 (2012) [ doi: 10.1016/j.chembiol.2012.10.010 ] Tarui Y, Chinen T, Nagumo Y, Motoyama T, Hayashi T, Hirota H, Muroi M, Ishii Y, Kondo H, Osada H, Usui T. Chembiochem, 15(7): 934-938 (2014) [ doi: 10.1002/cbic.201300808 ] Hongo Y, Nakamura T, Takahashi S, Motoyama T, Hayashi T, Hirota H, Osada H, Koshino H. J Mass Spectrom, 49(6): 537-542 (2014) [ doi: 10.1002/jms.3360 ] Motoyama T, Osada H. Bioorg Med Chem Lett, 26(24): 5843-5850 (2016) [ doi: 10.1016/j.bmcl.2016.11.013 ] Nagumo Y, Motoyama T, Hayashi T, Hirota H, Aono H, Kawatani M, Osada H and Usui T. ChemistrySelect, 2: 1533-6 (2017) [ doi: 10.1002/slct.201602015 ]