Original Articles 2010

  1. Nogawa T., Okano A., Takahashi S., Uramoto M., Konno H., Saito T., and Osada H.: Verticilactam, a new macrolactam isolated from a microbial metabolite fraction library.
    Org Lett, 12: 4564-4567, (2010). PubMed [ doi: 10.1021/ol1018618 ]
  2. Yoneda A., Ito T., Higaki T., Kutsuna N., Saito T., Ishimizu T., Osada H., Hasezawa S., Matsui M., and Demura T.: Cobtorin target analysis reveals that pectin functions in the deposition of cellulose microfibrils in parallel with cortical microtubules.
    Plant J, 64, 657-667 (2010) PubMed [ doi: 10.1111/j.1365-313X.2010.04356.x ]
  3. Lindqvist L., Robert F., Merrick W., Kakeya H., Fraser C., Osada H., and Pelletier J.: Inhibition of translation by cytotrienin A--a member of the ansamycin family.
    RNA, 16, 2404-2413 (2010) PubMed [ doi: 10.1261/rna.2307710 ]
  4. Hagiwara K., Murakami T., Xue G., Shimizu Y., Takeda E., Hashimoto Y., Honda K., Kondoh Y., Osada H., Tsunetsugu-Yokota Y., and Aida Y.: Identification of a novel Vpr-binding compound that inhibits HIV-1 multiplication in macrophages by chemical array.
    Biochem Biophys Res Commun, 403:, 40-45 (2010) PubMed [ doi: 10.1016/j.bbrc.2010.10.107 ]
  5. Sun, Y., Hahn, F., Demydchuk, Y., Chettle, J., Tosin, M., Osada, H.,and Leadlay, P. F.
    In vitro reconstruction of tetronate RK-682 biosynthesis.
    Nature Chem Biol, 6, 99-101 (2010) PubMed [ doi: 10.1038/nchembio.285 ]
  6. Kanoh, N., Takayama, H., Honda, K., Takashi Moriya, Teruya, T.,Simizu, S., Osada, H., and Iwabuchi, Y.
    Cleavable linker for photo-cross-linked small-molecule affinity matrix.
    Bioconjugate Chem, 21, 182-186 (2010) PubMed [ doi: 10.1021/bc900316q ]
  7. Kwon, O., Jeong, S. J., Kim, S. O., He, L., Lee, H. G., Jang, K. L., Osada, H., Jung, M., Kim, B. Y., and Ahn, J. S.
    Modulation of E-cadherin expression by K-Ras; involvement of DNA methyltransferase-3b.
    Carcinogenesis, 31: 1194-1201, (2010). PubMed [ doi: 10.1093/carcin/bgq071 ]
  8. Hagiwara, K., Kondoh, Y., Ueda, A., Yamada, K., Goto, H., Watanabe, T., Nakata, T., Osada, H., and Aida, Y.
    Discovery of novel antiviral agents directed against the influenza A virus nucleoprotein using photo-cross-linked chemical arrays.
    Biochem Biophys Res Commun, 9:,721-727,(2010) PubMed [ doi: 10.1016/j.bbrc.2010.03.058 ]
  9. Takeuchi, M., Kimura, S., Kuroda, J., Ashihara, E., Kawatani, M., Osada, H., Umezawa, K., Yasui, E., Imoto, M., Tsuruo, T., Yokota, A., Tanaka, R., Nagao, R., Nakahata, T., Fujiyama, Y., and Maekawa, T.
    Glyoxalase-I is a novel target against Bcr-Abl(+) leukemic cells acquiring stem-like characteristics in a hypoxic environment.
    Cell Death Differ, 17,1211-1220 (2010) PubMed [ doi: 10.1038/cdd.2010.6 ]
  10. Muroi, M., Kazami, S., Noda, K., Kondo, H., Takayama, H., Kawatani, M., Usui, T., and Osada, H.
    Application of proteomic profiling based on 2D-DIGE for classification of compounds according to the mechanism of action
    Chemistry & Biology, 17,460-470 (2010) PubMed [ doi: 10.1016/j.chembiol.2010.03.016 ]
  11. Takahashi, S., Takagi, H., Toyoda, A., Uramoto, M., Nogawa, T., Ueki, M., Sakaki, Y., and Osada, H.
    Biochemical characterization of a novel indole prenyltransferase from Streptomyces sp. SN-593.
    J Bacteriol, 192, 2839-2851 (2010) PubMed [ doi: 10.1128/JB.01557-09 ]
  12. Luo, Y., Li, W., Ju, J., Yuan, Q., Peters, N. R., Hoffmann, F. M., Huang, S., Bugni, T. S., Rajsk, S., Osada, H., and Shen, B.
    Functional characterization of TtnD and TtnF unveiling new insights into tautomycetin biosynthesis.
    J Am Chem Soc, 19, 6663-6671 (2010) PubMed [ doi: 10.1021/ja9082446 ]
  13. Yashiroda, Y., Okamoto, R., Hatsugai, K., Takemoto, Y., Goshima, N., Saito, T., Hamamoto, M., Sugimoto, Y., Osada, H., Seimiya, H., and Yoshida, M.
    A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor.
    Biochem Biophys Res Commun, 394, 569-573, (2010) PubMed [ doi: 10.1016/j.bbrc.2010.03.021 ]
  14. Nishida, H., Motoyama, T., Suzuki, Y., Yamamoto, S., Aburatani, H., and Osada, H.
    Genome-wide maps of mononucleosomes and dinucleosomes containing hyperacetylated histones of Aspergillus fumigatus.
    PLoS One, 5, e9916, (2010) PubMed [ doi: 10.1371/journal.pone.0009916 ]
  15. Miyazaki, I., Simizu, S., Okumura, H., Takagi, S., and Osada. H.
    A small-molecule inhibitor shows that pirin regulates migration of melanoma cells.
    Nature Chem Biol., 6,667-673,(2010) PubMed [ doi: 10.1038/nchembio.423 ]
  16. Ikedo, A., Hayakawa, I., Usui, T., Kazami, S., Osada, H., and Kigoshi, H.
    Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S(3) cells.
    Bioorg Med . Chem. Lett. (2010) PubMed [ doi: 10.1016/j.bmcl.2010.07.111 ]
  17. Na M, Thuong PT, Hwang IH, Bae K, Kim BY, Osada H and Ahn JS.
    Protein tyrosine phosphatase 1B inhibitory activity of 24-norursane triterpenes isolated from Weigela subsessilis.
    Phytother Res., 2010 PubMed [ doi: 10.1002/ptr.3203 ]
  18. Osada H.
    Introduction of new tools for chemical biology research on microbial metabolites.
    Biosci Biotechnol Biochem., 74, 1135-1140, (2010) PubMed
  19. Rydén AM, Ruyter-Spira C, Litjens R, Takahashi S, Quax W, Osada H, Bouwmeester H, Kayser O.: Molecular cloning and characterization of a broad substrate terpenoid oxidoreductase from Artemisia annua.
    Plant Cell Physiol, 51 (7): 1219-1228 (2010) PubMed [ doi: 10.1093/pcp/pcq073 ]
  20. Rydén AM, Ruyter-Spira C, Quax WJ, Osada H, Muranaka T, Kayser O, Bouwmeester H.: The molecular cloning of dihydroartemisinic aldehyde reductase and its implication in artemisinin biosynthesis in Artemisia annua.
    Planta Med, 76 (15): 1778-1783 (2010) PubMed [ doi: 10.1055/s-0030-1249930 ]
  21. Yamakoshi H, Kanoh N, Kudo C, Sato A, Ueda K, Muroi M, Kon S, Satake M, Ohori H, Ishioka C, Oshima Y, Osada H, Chiba N, Shibata H, Iwabuchi Y.: KSRP/FUBP2 is a binding protein of GO-Y086, a cytotoxic curcumin analogue.
    ACS Med Chem Lett, 1(6): 273-276 (2010) PMID: 24900207 [ doi: 10.1021/ml1000454 ]