Original Articles 2003

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1. Ganesh S, Tsurutani N, Suzuki T, Ueda K, Agarwala KL, Osada H, Delgado-Escueta AV, Yamakawa K.: The Lafora disease gene product laforin interacts with HIRIP5, a phylogenetically conserved protein containing a NifU-like domain.
   Hum Mol Genet, 12(18): 2359-2368 (2003) [ doi: 10.1093/hmg/ddg253 ]
2. Kakeya H, Miyake Y, Shoji M, Kishida S, Hayashi Y, Kataoka T, Osada H.: Novel non-peptide inhibitors targeting death receptor-mediated apoptosis.
   Bioorg Med Chem Lett, 13(21): 3743-3746 (2003) [ doi: 10.1016/j.bmcl.2003.08.003 ]
3. Shoji M, Kishida S, Kodera Y, Shiina I, Kakeya H, Osada H, Hayashi Y.: Reaction modes of oxidative dimerization of epoxycyclohexenols.
   Tetrahedron Lett., 44, 7205-7207 (2003) [url]
4. Woehlecke H, Osada H, Herrmann A, Lage H.: Reversal of breast cancer resistance protein-mediated drug resistance by tryprostatin A.
   Int J Cancer, 107(5): 721-728 (2003) [ doi: 10.1002/ijc.11444 ]
5. Kanoh N, Kumashiro S, Simizu S, Kondoh Y, Hatakeyama S, Tashiro H, Osada H.: Immobilization of natural products on glass slides by using a photoaffinity reaction and the detection of protein-small-molecule interactions.
   Angew Chem Int Ed Engl, 42(45): 5584-5587 (2003) [ doi: 10.1002/anie.200352164 ]
6. Su S, Kakeya, H, Osada, H, Porco, J.: Synthesis and cell cycle inhibition of the peptide enamide natural products terpeptin and the aspergillamides.
   Tetrahedron, 59, 8931-8946 (2003) [url]
7. Hayashi Y, Shoji M, Yamaguchi S, Mukaiyama T, Yamaguchi J, Kakeya H, Osada H.: Asymmetric total synthesis of pseurotin A.
   Org Lett, 5(13): 2287-2290 (2003) [ doi: 10.1021/ol034630s ]
8. Sekiyama Y, Palaniappan N, Reynolds KA, Osada H.: Biosynthesis of phoslactomycins cyclohexane carboxylic acid as the starter unit.
   Tetrahedron, 59, 7465-7471 (2003) [url]
9. Palaniappan N, Kim BS, Sekiyama Y, Osada H, Reynolds KA.: Enhancement and selective production of phoslactomycin B, a protein phosphatase IIa inhibitor, through identification and engineering of the corresponding biosynthetic gene cluster.
   J Biol Chem, 278(37): 35552-35557 (2003) [ doi: 10.1074/jbc.M305082200 ]
10. Maruyama M, Yagasaki Y, Sudo T, Osada H.: Renal abnormalities in mice caused by insufficiency of p38alpha.
    J Recept Signal Transduct Res, 23(2-3): 173-183 (2003) [ doi: 10.1081/rrs-120025197 ]
11. Nakamura M, Nakazawa J, Usui T, Osada H, Kono Y, Takatsuki A.: Nordihydroguaiaretic acid, of a new family of microtubule-stabilizing agents, shows effects differentiated from paclitaxel.
    Biosci Biotechnol Biochem, 67(1): 151-157 (2003) [ doi: 10.1271/bbb.67.151 ]
12. Simizu S, Ishida K, Wierzba MK, Sato TA, Osada H.: Expression of heparanase in human tumor cell lines and human head and neck tumors.
    Cancer Lett, 193(1): 83-89 (2003) [ doi: 10.1016/s0304-3835(02)00719-x ]
13. Nagashima F, Kondoh M, Kawase M, Simizu S, Osada H, Fujii M, Watanabe Y, Sato M, Asakawa Y.: [Apoptosis-inducing properties of ent-kaurene-type diterpenoids from the liverwort Jungermannia truncata].
    Planta Med, 69(4): 377-379 (2003) [ doi: 10.1055/s-2003-38888 ]
14. Kawatani M, Uchi M, Simizu S, Osada H, Imoto M.: Transmembrane domain of Bcl-2 is required for inhibition of ceramide synthesis, but not cytochrome c release in the pathway of inostamycin-induced apoptosis.
    Exp Cell Res, 286(1): 57-66 (2003) [ doi: 10.1016/s0014-4827(03)00098-3 ]
15. Miyake Y, Kakeya H, Kataoka T, Osada H.: Epoxycyclohexenone inhibits Fas-mediated apoptosis by blocking activation of pro-caspase-8 in the death-inducing signaling complex.
    J Biol Chem, 278(13): 11213-11220 (2003) [ doi: 10.1074/jbc.M209610200 ]
16. Nakazawa J, Yajima J, Usui T, Ueki M, Takatsuki A, Imoto M, Toyoshima YY, Osada H.: A novel action of terpendole E on the motor activity of mitotic Kinesin Eg5.
    Chem Biol, 10(2): 131-137 (2003) [ doi: 10.1016/s1074-5521(03)00020-6 ]
17. Otsu K, Yamashita N, Nishida K, Hirotani S, Yamaguchi O, Watanabe T, Hikoso S, Higuchi Y, Matsumura Y, Maruyama M, Sudo T, Osada H, Hori M.: Disruption of a single copy of the p38alpha MAP kinase gene leads to cardioprotection against ischemia-reperfusion.
    Biochem Biophys Res Commun, 302(1): 56-60 (2003) [ doi: 10.1016/s0006-291x(03)00096-2 ]