FSL0593

Structure

• InChI=1S/C17H17ClO6/c1-8-5-9(19)6-12(23-4)17(8)16(20)13-10(21-2)7-11(22-3)14(18)15(13)24-17/h6-8H,5H2,1-4H3/t8-,17+/m1/s1
• InChIKey=DDUHZTYCFQRHIY-RBHXEPJQSA-N

Synonyms

• 126-07-8
• 7- Chloro-4,6-dimethoxycoumaran-3-one-2-spiro-1'-(2'-methoxy-6'-methylcyclohex- 2'-en-3'-one)
• Amudane
• Anualane
• Anujane
• Curling Factor
• Fulvicin
• Gricin
• Grifulvin
• Grisactin
• Griseofulvin
• Grisovin
• NSC-34533

Origin

Penicillium griseofulvum

Biological activities

Inhibition of mitosis

Therapeutic

Antifungal

Target

Tubulin
Keratin

Assay information

Growth inhibition against Botrytis allii (25 μg/dish), Botrytis Cinirea (25 μg/dish), A. fumigatus (250 μg/ml), A. niger (5 μg/ml), A. clavatus (5 μg/ml), C. albicans (5 μg/ml)
Apoptosis induction in human cancer cells, HT29 (10 μM), COLO205 (10 μM), HepG2 (50 μM), Hep3B (20 μM), and HL60 (20 μM)

References

• Bhalodia NR, Shukla VJ
  Antibacterial and antifungal activities from leaf extracts of Cassia fistula l.: An ethnomedicinal plant.
  J Adv Pharm Technol Res, 2(2): 104-109 (2011)  22171301  doi: 10.4103/2231-4040.82956
• Singh B, Maheshwari A, Dak G, Sharma K, Talesara GL
  Studies of Antimicrobial Activities of some 4-Thiazolidinone Fused Pyrimidines, [1,5]-Benzodiazepines and their Oxygen Substituted Hydroxylamine Derivatives.
  Indian J Pharm Sci, 72(5): 607-612 (2010)  21694993  doi: 10.4103/0250-474X.78529
• Ho YS, Duh JS, Jeng JH, Wang YJ, Liang YC, Lin CH, Tseng CJ, Yu CF, Chen RJ, Lin JK
  Griseofulvin potentiates antitumorigenesis effects of nocodazole through induction of apoptosis and G2/M cell cycle arrest in human colorectal cancer cells.
  Int J Cancer, 91(3): 393-401 (2001)  11169965
• Ko BS, Oritani T, Yamashita K
  Synthesis and biological activities of griseofulvin analogs.
  Agric Biol Chem, 54(9): 2199-2204 (1990)  1368574
• Oxford AE, Raistrick H, Simonart P
  Studies in the biochemistry of micro-organisms: Griseofulvin, C(17)H(17)O(6)Cl, a metabolic product of Penicillium griseo-fulvum Dierckx.
  Biochem J, 33(2): 240-248 (1939)  16746904