FSL0868

Structure

• InChI=1S/C22H30O3/c1-13-10-14(23)17-15(11-13)25-21(4)9-6-16-20(2,3)7-5-8-22(16)12-24-18(17)19(21)22/h10-11,16,18-19,23H,5-9,12H2,1-4H3/t16-,18-,19-,21-,22-/m0/s1
• InChIKey=UGGAILYEBCSZIV-ITJSPEIASA-N

Synonyms

• 22733-60-4
• Siccanin

Origin

Helminthosporium siccans

Biological activities

Inhibition of succinate dehydrogenase

Therapeutic

Antifungal

Target

Succinate dehydrogenase

Assay information

Inhibits succinate dehydrogenase (IC₅₀: 900 nM)
Antibacterial activity against Trichophyton mentagrophytes (IC100: 3 μg/ml, IC₅₀: 0.03 μg/ml)

References

• Mogi T, Kawakami T, Arai H, Igarashi Y, Matsushita K, Mori M, Shiomi K, Omura S, Harada S, Kita K
  Siccanin rediscovered as a species-selective succinate dehydrogenase inhibitor.
  J Biochem, 146(3): 383-387 (2009)  19505951  doi: 10.1093/jb/mvp085
• Hirai K, Okuda S, Nozoe S, Iitaka Y
  The crystal and molecular structure of siccanin p-bromobenzenesulphonate.
  Acta Crystallogr B, 25(12): 2630-2638 (1969)  5395581
• J. Antibiot., 15: 161-167 (1962)