FSL0718

Structure

• InChI=1S/C23H46N6O13/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22/h5-23,30-36H,1-4,24-29H2/t5-,6?,7?,8?,9?,10?,11?,12?,13-,14-,15?,16+,17?,18-,19-,20+,21-,22-,23?/m1/s1
• InChIKey=PGBHMTALBVVCIT-OQKLYHBQSA-N

Synonyms

• 10676
• 119-04-0
• 956
• Actilin
• Colimycin
• Dextromycin
• EF-185
• Fradiomycin
• Framycetin
• Mycerin
• Neomycin B
• Roseomycin
• Soframycin
• Streptothricin-B-II

Origin

Streptomyces fradiae

Biological activities

Inhibition of prokaryotic protein synthesis

Therapeutic

Antibacterial

Target

30S ribosomal protein S12

Assay information

Exhibition of antibacterial activity against Staphylococcus. aureus (MIC 1 μg/mL), MRSA (MIC 256 μg/mL), S. epidermidis (MIC 0.25 μg/ml), S. pneumoniae (MIC 8 μg/mL), Escherichia coli (MIC 2 μg/mL), E. coli (Gent-R) (MIC 4 &m

References

• Bera S, Zhanel GG, Schweizer F
  Synthesis and antibacterial activity of amphiphilic lysine-ligated neomycin B conjugates.
  Carbohydr Res, 346(5): 560-568 (2011)  21353205  doi: 10.1016/j.carres.2011.01.015
• J. Am. Chem. Soc., 76: 1045-1046 (1950)
• Waksman SA, Lechevalier HA
  Neomycin, a New Antibiotic Active against Streptomycin-Resistant Bacteria, including Tuberculosis Organisms.
  Science, 109(2830): 305-307 (1949)  17782716  doi: 10.1126/science.109.2830.305