FSL0721

Structure

• InChI=1S/C16H18N4O2/c21-15(18-12-13-4-2-1-3-5-13)8-11-19-20-16(22)14-6-9-17-10-7-14/h1-7,9-10,19H,8,11-12H2,(H,18,21)(H,20,22)
• InChIKey=NOIIUHRQUVNIDD-UHFFFAOYSA-N

Synonyms

• 51-12-7
• Nialamide

Origin

Chemically synthesized

Biological activities

Increasing the concentrations of various neurotransmitters, such as serotonin, epinephrine and dopamine

Therapeutic

Antidepressant

Target

Monoamine oxidase

Assay information

Inhibition of MAO-A (EC50 = 2.6 μM) and MAO-B (EC50 = 13 μM) in rat brain homogenates

References

• Ulus IH, Maher TJ, Wurtman RJ
  Characterization of phentermine and related compounds as monoamine oxidase (MAO) inhibitors.
  Biochem Pharmacol, 59(12): 1611-1621 (2000)  10799660
• Benady DR, Clein LJ, Pare CM
  Intramuscular nialamide in intractable depression.
  Dis Nerv Syst, 26(12): 792-794 (1965)  5321917
• VAISBERG M, McGAHEE CL, RADINGER N, SAUNDERS JC
  Nialamide for the treatment of anergy and depression.
  Dis Nerv Syst, 20(Suppl): 22-25 (1959)  13840714