FSL0569

Structure

• InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1
• InChIKey=OVBPIULPVIDEAO-LBPRGKRZSA-N

Synonyms

• 59-30-3
• folic acid
• Folic acid
• MS0A0620
• NP369

Origin

Biological activities

Essential nutrient for metabolic maintenance and nucleotide biosynthesis

Therapeutic

Vitamin

Target

Folate receptors (FRα, FRβ, FRγ)

Assay information

Binding to folate receptors (K_d = ~ 100 pM)

References

• Chen C, Ke J, Zhou XE, Yi W, Brunzelle JS, Li J, Yong EL, Xu HE, Melcher K
  Structural basis for molecular recognition of folic acid by folate receptors.
  Nature, 500(7463): 486-489 (2013)  23851396  doi: 10.1038/nature12327
• Leamon CP, Jackman AL
  Exploitation of the folate receptor in the management of cancer and inflammatory disease.
  Vitam Horm, 79: 203-233 (2008)  18804696  doi: 10.1016/S0083-6729(08)00407-X
• Raiten DJ, Fisher KD
  Assessment of folate methodology used in the Third National Health and Nutrition Examination Survey (NHANES III, 1988-1994).
  J Nutr, 125(5): 1371S-1398S (1995)  7738698