FSL0424

Structure

• InChI=1S/C17H20N2O5S/c1-2-3-9-19-14-10-12(17(20)21)11-15(25(18,22)23)16(14)24-13-7-5-4-6-8-13/h4-8,10-11,19H,2-3,9H2,1H3,(H,20,21)(H2,18,22,23)
• InChIKey=MAEIEVLCKWDQJH-UHFFFAOYSA-N

Synonyms

• 28395-03-1
• Bumetanide

Origin

Chemically synthesized

Biological activities

Sodium potassium chloride symporter Inhibitors

Therapeutic

Diuretic (loop diuretic)
Heart failure

Target

NKCC1 cation-chloride co-transporter

Assay information

Na-K-Cl cotransporter (NKCC1) decreases internal chloride concentration in neurons (Affinity: ca 0.5 μM)

References

• Somasekharan S, Tanis J, Forbush B
  Loop diuretic and ion-binding residues revealed by scanning mutagenesis of transmembrane helix 3 (TM3) of Na-K-Cl cotransporter (NKCC1).
  J Biol Chem, 287(21): 17308-17317 (2012)  22437837  doi: 10.1074/jbc.M112.356014
• Asbury MJ, Gatenby PB, O'Sullivan S, Bourke E
  Bumetanide: potent new "loop" diuretic.
  Br Med J, 1(5794): 211-213 (1972)  4550872