FSL0312

Structure

• InChI=1S/C18H28N2O4.ClH/c1-5-6-18(23)20-14-7-8-17(16(9-14)13(4)21)24-11-15(22)10-19-12(2)3;/h7-9,12,15,19,22H,5-6,10-11H2,1-4H3,(H,20,23);1H
• InChIKey=KTUFKADDDORSSI-UHFFFAOYSA-N

Synonyms

• 34381-68-5
• Acebutolol hydrochloride

Origin

Chemically synthesized

Biological activities

β-adrenoreceptor antagonist
Mild intrinsic sympathomimetic activity

Therapeutic

Antiangina
Antiarrhythmic (class II)
Antihypertensive

Target

Selective β1-adrenergic receptors

Assay information

Effects on the activation of Adenylate cyclase from heart and liver induced by 1-isoproterenol (IC₅₀ [μM]): Heart (9.0), Liver (838.9)
Isoprenaline-induced tachycardia and diastolic hypotension antagonize avtivity

References

• Folia Pharmacol. Japon, 73: 591-396 (1977)
• Br. J. Pharmac., 48: 198-211 (1973)
• Cuthbert MF, Owusu-Ankomah K
  Effect of M & B 17803A, a new -adrenoceptor blocking agent, on the cardiovascular responses to tilting and to isoprenaline in man.
  Br J Pharmacol, 43(3): 639-648 (1971)  4400530