FSL0522

Structure

• InChI=1S/C41H64O13/c1-20-36(46)29(42)16-34(49-20)53-38-22(3)51-35(18-31(38)44)54-37-21(2)50-33(17-30(37)43)52-25-8-11-39(4)24(15-25)6-7-28-27(39)9-12-40(5)26(10-13-41(28,40)47)23-14-32(45)48-19-23/h14,20-22,24-31,33-38,42-44,46-47H,6-13,15-19H2,1-5H3/t20-,21-,22-,24-,25+,26-,27?,28?,29+,30+,31+,33+,34+,35+,36-,37-,38-,39+,40-,41+/m1/s1
• InChIKey=WDJUZGPOPHTGOT-KSVSUYAUSA-N

Synonyms

• 71-63-6
• Digitoxin
• MS0A0139

Origin

Digitalis purpurea

Biological activities

Na⁺/K⁺ ATPase membrane pump inhibition

Therapeutic

Antiarrhythmic
Cardiotonic

Target

Na⁺/K⁺-ATPase

Assay information

Na⁺/K⁺ ATPase inhibition (2.8 μM)
The antiproliferative and apoptotic effects in several cancer cell lines: NCI-H460 cells, IC₅₀ = 49.8 nM

References

• Elbaz HA, Stueckle TA, Wang HY, O'Doherty GA, Lowry DT, Sargent LM, Wang L, Dinu CZ, Rojanasakul Y
  Digitoxin and a synthetic monosaccharide analog inhibit cell viability in lung cancer cells.
  Toxicol Appl Pharmacol, 258(1): 51-60 (2012)  22037315  doi: 10.1016/j.taap.2011.10.007
• Prassas I, Diamandis EP
  Novel therapeutic applications of cardiac glycosides.
  Nat Rev Drug Discov, 7(11): 926-935 (2008)  18948999  doi: 10.1038/nrd2682
• Watson E, Tramell P, Kalman SM
  Identification of submicrogram amounts of digoxin, digitoxin, and their metabolic products. Isolation by chromatography and preparation of derivatives for assay by electron capture detector.
  J Chromatogr, 69(1): 157-163 (1972)  5039625