FSL0281

Structure

• InChI=1S/C8H16N2O2S2/c1-5-11-6-2-9(1)13-14-10-3-7-12-8-4-10/h1-8H2
• InChIKey=HLBZWYXLQJQBKU-UHFFFAOYSA-N

Synonyms

• 103-34-4
• 4,4'-Dithiodimorpholine

Origin

Chemically synthesized

Biological activities

Inhibition of cell viability and induction for apotosis.

Therapeutic

Anticancer
Antiviral

Target

HPV E6 protein

Assay information

Inhibition of the growth of the tumorigenic HPV (human papillomavirus) cell lines SiHa, CaSki, and HeLa at concentrations of 50 μM
Inhibition of cell vibility of tumor and non-tumor cells: PHFK (LD₅₀: 25.1, 25.8, 24.0 μM (24, 48, 72h)), C33A (LD₅₀: 26.4, 28.9, 22.9 μM (24, 48, 72h)), SiHa (LD₅₀: 42.3, 35.1, 31.6 μM (24, 48, 72h

References

• Zehbe I, Richard C, Lee KF, Campbell M, Hampson L, Hampson IN
  Lopinavir shows greater specificity than zinc finger ejecting compounds as a potential treatment for human papillomavirus-related lesions.
  Antiviral Res, 91(2): 161-166 (2011)  21669231  doi: 10.1016/j.antiviral.2011.05.016
• Beerheide W, Bernard HU, Tan YJ, Ganesan A, Rice WG, Ting AE
  Potential drugs against cervical cancer: zinc-ejecting inhibitors of the human papillomavirus type 16 E6 oncoprotein.
  J Natl Cancer Inst, 91(14): 1211-1220 (1999)  10413422
• Heydenreich G, Olholm-Larsen P
  4,4'-dithiodimorpholine, a new rubber sensitizer.
  Contact Dermatitis, 2(5): 292-293 (1976)  138524