FSL0342

Structure

• InChI=1S/C33H40O21/c1-9-19(39)22(42)25(45)31(49-9)48-8-17-29(53-32-26(46)23(43)20(40)16(7-34)51-32)24(44)27(47)33(52-17)54-30-21(41)18-14(38)5-11(35)6-15(18)50-28(30)10-2-3-12(36)13(37)4-10/h2-6,9,16-17,19-20,22-27,29,31-40,42-47H,7-8H2,1H3/t9-,16+,17+,19-,20+,22+,23-,24+,25+,26+,27?,29+,31+,32+,33-/m0/s1
• InChIKey=PFPQMWRASYNLMZ-CWZDVQAVSA-N

Synonyms

• alpha-Glucosylrutin

Origin

Chemically synthesized

Biological activities

Chelating trace metals and scavenging free radicals

Therapeutic

Antioxidant

Target

Trace metals (Fe/Cu), free radical

Assay information

Antioxidant activity
Protection from ferric nitrilotriacetate (Fe-NTA)-induced renal damage by chelating of ferric ions in ICR mice
Prevention of dermatologic diseases in which oxidative stress is of pathogenetic relevance, e.g. in polymorphous light eruption
Promising dermato-cosmetic areas for AGR application are aging of the skin, especially photoaging

References

• Wolber R, Stäb F, Max H, Wehmeyer A, Hadshiew I, Wenck H, Rippke F, Wittern KP
  [Alpha-glucosylrutin, a highly effective flavonoid for protection against oxidative stress].
  J Dtsch Dermatol Ges, 2(7): 580-587 (2004)  16281620
• Pietta PG
  Flavonoids as antioxidants.
  J Nat Prod, 63(7): 1035-1042 (2000)  10924197
• Shimoi K, Shen B, Toyokuni S, Mochizuki R, Furugori M, Kinae N
  Protection by alpha G-rutin, a water-soluble antioxidant flavonoid, against renal damage in mice treated with ferric nitrilotriacetate.
  Jpn J Cancer Res, 88(5): 453-460 (1997)  9247601
• Suzuki Y, Suzuki K
  Enzymatic formation of 4G-alpha-D-glucopyranosyl-rutin.
  Agric Biol Chem, 55(1): 181-187 (1991)  1368662