FSL0806

Structure

• InChI=1S/C17H23N5O14/c18-5(7(24)4(23)2-35-16(19)33)12(28)20-6(15(31)32)10-8(25)9(26)13(36-10)22-1-3(14(29)30)11(27)21-17(22)34/h1,4-10,13,23-26H,2,18H2,(H2,19,33)(H,20,28)(H,29,30)(H,31,32)(H,21,27,34)/t4-,5-,6-,7+,8-,9+,10?,13?/m0/s1
• InChIKey=JPFWJDMDPLEUBD-FCQOVDMSSA-N

Synonyms

• 22976-86-9
• Polyoxin D
• Polyoxin D
• Polyoxin-D

Origin

Streptomyces cacaoi var. asoensis

Biological activities

Inhibition of fungal cell wall biosynthesis

Therapeutic

Antifungal

Target

Chitin synthase

Assay information

Inhibition of fungal chitin synthases (K_i = 1.4 μM)
Growth inhibition of some filamentous fungi (plant invaders) (MIC [μg/ml]): P. oryzae (3.12), C.myabiannus (6.25), and P. filamentosa (

References

• Endo A, Kakiki K, Misato T
  Mechanism of action of the antifugal agent polyoxin D.
  J Bacteriol, 104(1): 189-196 (1970)  5473886
• Isono K, Asahi K, Suzuki S
  Studies on polyoxins, antifungal antibiotics. 13. The structure of polyoxins.
  J Am Chem Soc, 91(26): 7490-7505 (1969)  5358618  doi: 10.1021/ja01054a045
• Endo A, Misato T
  Polyoxin D, a competitive inhibitor of UDP-N-acetylglucosamine: chitin N-acetylglucosaminyltransferase in Neurospora crassa.
  Biochem Biophys Res Commun, 37(4): 718-722 (1969)  5353899
• Kiyoshi ISONO, Junsaku NAGATSU, Kimie KOBINATA, Kazuya SASAKI, Saburo SUZUKI
  Studies on Polyoxins, Antifungal Antibiotics Part V. Isolation and Characterization of Polyoxins C, D, E, F, G, H and I
  Agri. Biol. Chem., 31: 190-199 (1967)  doi: 10.1271/bbb1961.31.190
• Saburo SUZUKI, Kiyoshi ISONO, Junsaku NAGATSU, Yoshio KAWASHIMA, Kimie YAMAGATA, Kazuya SASAKI, Kensuke HASHIMOTO
  Studies on Polyoxins, Antifungal Antibiotics Part IV Isolation of Polyoxins C, D, E, F and G, New Components of Polyoxin Complex
  Agri. Biol. Chem., 30: 817-819 (1966)  doi: 10.1271/bbb1961.30.817